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And if you have old saves from before the newest DW2 was released, make sure you discard those as well - they might work and they might not. Better for stability to start a new game.
1. verifying the game files
2. deselect all mods in the mod menu :: restart the game engine :: start a new game
You can deselect all of your games if you navigate to the game folder and delete the mods.json file in the mods subfolder.
On my installation, this is located at:
C:\Steam\steamapps\common\Distant Worlds 2\mods\mods.json