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It seems that when calyxanide and vanilla huskinfectionresistance is combined, the following happens:
1) husk infection will tick down past the 25% stop threshold (potentially all the way down to 0 and be cured),
2) the surgery minigame will repeatedly spawn a new husk parasite if the previous is removed with a hemostat,
3) the giveaffliction huskinfection command is inverted, making negative values grow the targets huskinfection instead of decreasing, and vice versa.
At least this is what it seems like is happening. In that case there are two way of avoiding this (probably bug right?):
1) never apply broad-spectrum antibiotics to someone with husk infection.
2) never apply calyxanide to someone with husk infection (at 100 medical skill, you can complete the entire surgery safely without calyxanide)