What you will need for this, is a chaingun with the "Mobile Turret" upgrade, max out the upgrade if possible, and a Super Shotgun with mastery

If you had maxed out ammo before you entered the boss fight, start emptying the Chaingun into Khan Maykr, ignore her minions, just fire, after her shield is gone, hook up to her and punch her, after you do that wait for your hook to regen and headshot one of her minions to get back health and ammo, repeat until she's dead, if you have no ammo, kill some minions for ammo and health and then start firing.

I did this on maxxed out Preator suit, if you dont have it the strat might not work, i dont know though i did NOT test it with no or little upgrades, so thats a little heads up