Yeah I've had that one before too... Making me sell a joker usually sucks because I depend on everything I have. I guess the joker to have in that case is the "sell this joker to disable the boss blind" joker. The "one card is always selected" is easy by comparison. You just make a hand with that one card (and if it's 2 pair, that one card can just be a throwaway). also even if you have to make a 5 card hand, you can discard the "always selected" card and make it choose another.

This game is so satisfying isn't it? I just won my first run. Your final boss Blind was definitely scary compared to mine, which made me sell a joker or all cards in the deck were debuffed. Luckily I had one that ran out of usefulness.

This time I played with the spectral deck and didn't use the lame "add polychrome to joker and destroy all others" card. I got a different spectral card that allowed me to duplicate a joker and since I had a good "2 pair" joker with +10 Multi Holographic, I duplicated that, and then for the rest of the game I played mostly two pair and full house (which contains a two pair). Oh and the best part was that for my 4th joker I had the "mr bones" joker that saves you from death, and after it triggered, I was able to buy it right back, but I didn't need it.