The action takes place in the city of Raccoon City. After the leak of the T-Virus, a real war between the living and the dead unfolds on the streets of the city. In the end, only a few survivors remain, one of whom is Jill Valentine. She tries to leave the city and help other survivors, but Nemesis stands in her way, whose main goal is to destroy the remaining members of the S.T.A.R.S.

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• After killing Brad, Nemesis throws his corpse aside and rushes after the heroine. Jill, depending on the player’s choice, can immediately run away to the police station, or try to pick up Bred’s ID card, and only then go to the police station, or fight back Nemesis. When Valentine ends up in the precinct, Nemesis cannot follow her through the tightly sealed main entrance, however, after Jill is in the office "S.T.A.R.S." contacts Carlos Oliveira via radio, the monster gets inside through the window and continues to hunt the heroine, but with a rocket launcher in service. Jill, however, can escape from the site in order to avoid persecution, or fight back Nemesis again.
  
  
• While moving around the infected city, Jill encounters Nemesis several more times, and each time she will be able to either knock him out or get away from him with great difficulty. Meeting with Oliveira and his squad in the funicular, Valentine continues his dangerous escape through the city, but once again the heroes are overtaken by Nemesis. Easily bursting inside the carriage, he encounters a wounded mercenary "U.B.C.S." Mikhail Victor, who, sacrificing his life, detonates a grenade, thereby temporarily incapacitating the monster, exploding in the process the whole carriage.
  
  
• Even though Jill manages to reach the clock tower located in the northern part of the city, Nemesis continues to tirelessly follow her, catching her on the tower's balcony. At the player's choice, the heroine can throw an electric wire into the puddle in which Nemesis is standing, thereby stunning him for a while, or blind him with the help of a spotlight, and then push him off the balcony. After this, Jill rings the bell, thereby calling for a rescue helicopter, but at the same moment Nemesis returns and shoots down the helicopter with a portable rocket launcher. Among the burning ruins, Jill encounters Nemesis in battle in the courtyard of the tower. Even before the battle begins, the monster manages to infect Valentine with the T-virus, using the same tentacle with which he previously killed Vickers. However, the barrage of fire that followed from Jill after this made it possible to repel the monster’s attack. Seriously wounded, Nemesis retreats and falls into the fire. As a result, the monster's cloak almost completely burns out, and Nemesis itself begins to mutate uncontrollably, as a result of which many writhing tentacles burst out of its body.
  
  
• This seemingly invincible monster reappears when Carlos returns from the local hospital with a vaccine for the wounded Jill. Breaking his way through a brick wall and waving his many tentacles, he tries to stop Carlos and get to Jill in order to kill her, but he still manages to deliver the medicine for Valentine. Although Jill subsequently manages to hide from the monster in the city park, she encounters him again on the bridge leading to the Dead Factory, and she has to jump into the river. Already at the enterprise, Valentine fights with Nemesis in the waste disposal room. Jill manages to inflict severe burns on the monster with the help of chemicals, as a result of which he, having lost his arms and head, falls dead, after which the opened hatches of the room dump his remains into a pool filled with a recycling substance.
  
  
• Believing that Nemesis is finished, Jill heads to the plant's power plant in hopes of finding a way to leave the city. Inside, she discovers evidence of a battle between the Special Forces Squad and the B.O.O. Umbrella, as well as a huge railgun installed indoors. The next moment, Nemesis reappears, having somehow survived the acid plunge. The creature, now nothing more than a formless pile of flesh, approaches the remains of the Tyrant T-103 and consumes it. This leads to the final mutation, making Nemesis a huge creature covered in tentacles, becoming even more resistant to damage and capable of spitting deadly poison over long distances, but in the process losing the last vestiges of his intelligence.
  
  
• Jill quickly realizes that her only key to survival is the railgun. After several direct hits from the installation on the monster, the latter finally seems defeated. But as soon as Valentine heads towards the exit, Nemesis begins to show signs of life. Wanting to finish off his pursuer once and for all, Jill picks up a discarded magnum and discharges the entire drum into the monster, after which it finally dies, and its remains begin to slowly dissolve. However, it is worth noting that, at the will of the player, Jill can simply leave, leaving the monster in the room, and therefore it can be assumed that he dies as a result of his wounds, or will be destroyed along with the city at the moment of his annihilation.
  
  

● First Escape
Escape from Jill's apartment building

This one you will get when you will escape Nemesis for the first time and leave the building.

● Somebody to Lean On
Escape from uptown Raccoon City

This achievement you will get after car accident with Nemesis and getting into subway.

● Nemesis Down?
Defeat Nemesis on the rooftop

That one you will get after first Nemesis boss fight at the rooftop of burning building. Shoot the canister at his back to deal him damage and make him lose flamethrower, what will make fight easier.

● Escape from the City
Make it out of Downtown Raccoon City

Story related, cannot be missed. This achievement you will get when you enter subway train.

● The Carlos Express
Leave R.P.D.

This one you will get after Carlos's way through R.P.D. to S.T.A.R.S. office. Be careful when you enter west site of R.P.D. i mean corridor after the door you have to unlock because there are many zombies. The best way is to go back into small room and lure them into. When they break into shoot in the head with machine gun. Remember to always check with knife or gun if zombie is really dead.

● I Don't Feel So Good
Leave the clock tower plaza

This one you will get after Nemesis 2nd boss fight. The best option is to use flaming rounds in grenade launcher because its give him a short stun so you can stop dangerous rush. Try to do perfect dodge, then fast use the advantage that you will automatically aim for head to deal him massive damage with shotgun.

● I Need a Hero
Withstand the zombie siege

This one you will get after Carlos's part of the game in hospital, when you get the vaccine for Jill and use it to cure her you will have to face a lot of enemies. It will be survival with waves of enemies but the thing if you survive is not the most important because you have to protect the door that leads to Tyrell and Jill because if zombies break into, the game ends and you have to try again. There are not only zombies but Infected by NE-α parasite zombies and 2 hunters.

● The Pursuer
Follow Nicholai deeper underground

This achievement you will get when you enter the lab section. Its just after the warehouse where you have to find 3 fuses.

● Nemesis Down!?
Defeat Stage 2 Nemesis

This achievement you will get after Nemesis 3rd boss fight. The same as in the 2nd fight use flaming rounds for stun and use perfect dodge. You also have to be prepared for enemies that will spawn in the fight area. You can avoid them or kill them. When Nemesis starts to run outside the arena check where is he, because if he stops running around you will have to shoot the button next to him to bring him down and have a possibility to deal him big damage.

● Nemesis Down!!!
Defeat Stage 3 Nemesis

This achievement you will get after Nemesis 4th boss fight. In this fight you will have to do perfect dodge (Its the most important at nightmare and inferno difficulty.) and shoot the Nemesis's tumors to make him fall to the ground. Then you will have have a possibility to place the cores back into position and if you do it 3 times you will use the "FINGER" to kill him once and for all.

● Power Stones
Place all jewels in the clock tower monument

There are 3 jewels that you need to use in the monument just before you go from the subway on the street. They are hidden in fancy boxes. First Fancy Box with red jewel you will find in Moon's Donuts' safe room. The 2nd Fancy Box with green jewel you will find in the Toy Uncle Supershop and to open it you have to use lockpick. The 3rd Fancy Box with blue jewel you will find in the Supermarket across the street from the 2nd Fancy Box and to get into you in bolt cutters.

● Hello, Charlie!
Destroy a Charlie Doll

Check "Goodbye, Charlie!" achievement description.

● Goodbye, Charlie!
Destroy all Charlie dolls

There are a total of 20 Mr. Charlie Dolls in the game. When you will be close to it you will hear specific sound.

● Get Organized
Expand your inventory

To get this you have to find the hip pouch. First one in the game you will find in the room just before you enter the area with deimos's.

● Gunsmith
Improve a weapon

As in description you have to find a weapon part. First one you will find in storage room with a safe near a body on the floor. Use the combination of 9 left , 3 right, 7 left.

● Kendo's Armory
Collect all weapons in the campaign

There are 4 weapons that you have to collect to get this achievement:

• M3 Shotgun - located in the Kite Bros. Office building. Use the bolt cutters to get it
  
• MGL Grenade Launcher - located in sewers, when you slide down go straight ahead and dont turn right. You will encounter one Hunter Gamma, kill him and climb the ladder, you will find that weapon in the office.
  
• G18 Handgun (Burst Model) - located in hospital, its in the room where Jill wakes up after Carlos's defense, close to door.
  
• 44 AE Lighting Hawk - located in hospital, go on the first floor, then go through a crawl space where Carlos couldnt go into and jump out the window to the courtyard.

● RE: Master of Unlocking
Unlock all safes, lockers, strongboxes, and pickable locks

There are 20 places where you have to open. Chest which has no padlock doesnt count for this achievement.

● Bookworm
Read all story files

There are a total of 56 files within the game you have to obtain.

● Survivor
Complete the game on "Standard" or higher

This difficulty level is not hard. Enemies are slow and deals not many damage, there are more items like ammo or herbs that will make this run a lot easier. Study how locations looks like to be prepared for higher difficulty levels.

● Veteran
Complete the game on "Hardcore" or higher

This is the highest difficulty that you will can play while first encounter. Enemies deals more damage than on "Standard", but they are still slow. The next difference is that you will find less items like ammo or herbs. If you finish game on this difficulty level you will unlock "Nightmare" difficulty. If its you first encounter you will also unlock "Survivor" achievement.

● Conqueror
Complete the game on "Nightmare" or higher

To have a possibility to play on this difficulty level you have to finish the game on hardcore difficulty.
On this difficulty enemies are very fast and agressive and deal more damage than on hardcore. Enemies and items appear in different localizations so you will only know how map looks like and you have to be careful and ready for everything. If you finish game on this difficulty level you will unlock "Inferno" difficulty.

● Dominator
Complete the game on "Inferno"

To unlock "Inferno" difficulty, you have to complete the game on "Nightmare" difficulty first. This is the hardest difficulty that you will encounter. Enemies deals horrible damage and can kill you with one hit. Conserve ammo and healing items, you will need it. You will also need patience because in this difficulty there will be no checkpoints so if you have a chance, save the game because there will be less typewriters and item boxes in the game. To make it easier you can purchase items like infinite rocket launcher from the shop.

● Jill Valentine
Complete the game with an S rank on "Inferno"

Check "Dominator" and "Sprinter" achievement description for more tips. Its the hardest achievement in the game and great challenge. If you want to make it as easy as it can be you will need infinite rocket launcher and all coins. With this equipment it should not be a big deal, but if you want to do it without boosters you should be prepared for nightmare.

● Sensational Work!
Complete the game with an S rank

Check "Sprinter" achievement description for more tips to speedrun. To get S rank you have to finish the game in certain time which is depending on the difficulty level and with at most 5 saves on any difficulty level. If you want to check requirements for every difficulty check "results" in main menu.

● Sprinter
Complete the game in under 2 hours of play time

You can get this achievement on any difficulty level, what can make it extremaly easy on Assisted difficulty. Go only where you have to progress in story. If you die, do not choose "retry" option because the time spent in-between will be counted, just reload save. If you skip cutscenes you will also can save some time. You can also use items from shop like infinite rocket launcher or coins. You can also obtain "I Might Need These Later!" and "Sensational Work!" and "Minimalist" achievements during this playthrough.

● Basic Chemistry
Craft an item

As in description you have to craft an item by combining 2 items. It can be for example 2 green herbs, one green herb and red herb.

● An Unfortunate End
Defeat zombie Brad

As in description you have to kill zombie Brad. You will meet him at the beginning of Carlos's chapter on R.P.D. Just shoot him as long as he is not dead.

● Nemesis Down
Cause Nemesis to relinquish an item

You can get this achievement in Downtown after Nemesis first appearance. To make him relinquish an item you have to deal him enough damage to make him fall on the knee. The easier way is to use grenade or red barrels.

● Two For One Deal
Defeat two enemies with a single shot

As in description you have to kill 2 enemies with one shot. You can get it easily with grenade launcher or with shotgun on Deimos's.

● Electric Slide
Gather the fuses in the warehouse within 5 minutes

As in description you have to speedrun through warehouse.

● I Might Need These Later!
Complete the game using 1 or fewer recovery items

As stated in the description, you can't use more than 1 recovery item such as herbs or first aid spray, but you won't need it if you have recovery coins that restore health. Avoid taking damage and do it on easy difficulty to make it as easy as possible. According to the plot, you will have to use health restoration once (in front of the power station after you are infected). So in this walkthrough you cannot use health restoration items at all.

● Minimalist
Complete the game without opening the item box

As stated in the description, you cannot open the item box, so you need to manage your inventory space well and this will not be a problem. Do this on easy difficulty levels to make the task as simple as possible. For me personally, this is the most difficult achievement in all games, but I can wish you good luck in achieving it.

• I am a fan of the Resident Evil series of games and I really liked this part of the game, after the first playthrough I want to play it again. I beat the game on all difficulties at rank "S" and got all the achievements. I recommend everyone to play and get all the achievements in the game. In my opinion, this game has the easiest achievements of any Resident Evil game. Have a good game everyone and thanks for watching. If this guide helped you, please give it a thumbs up to make it easier for others to find.
  
  

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