Short guide on what I had to do in order to get this game up and running. System is Windows 11 running on a 13900k. Dead Space does not like running on systems with a new OS (such as Windows 11), or on processors with a high core count (like a 13900k). So I got the worst of both worlds and had to manually fix the game in order to play it.

1. Right click on the game in Steam, go to PROPERTIES/LOCAL FILES/BROWSE. This will take you to the main game directory.
   
   
2. Locate "Dead Space.exe," right click on it, PROPERTIES/COMPATIBILITY. Select "Run this program in compatibility mode for:" and in the drop-down menu immediately below it, select "Windows 7." NOTE: If Windows 7 does not work, try an older version. For me, both Windows 7 and Windows Vista worked.
   
   
3. Hit APPLY, then OK.
   
4. Go to C:\Users\[YOUR USERNAME]\Documents\Electronic Arts\Dead Space. IF YOU HAVE SAVES: copy your saves inside the Dead Space folder and paste them somewhere safe for now.
   
   
5. Go back to C:\Users\[YOUR USERNAME]\Documents and delete "Electronic Arts" along with everything inside.

At this point, try to launch the game. If it works, great. That's it. You're done.
If you had save files, let the game go to the main menu, then exit out. Move the save files back into the C:\Users\[YOUR USERNAME]\Documents\Electronic Arts\Dead Space folder.

IF THE GAME DID NOT LAUNCH:

1. Download Process Lasso[bitsum.com]. You only need the free version. This program allows you to control your CPU and how many cores processes can use. This is a useful functionality, as some games (like Dead Space) freak out when they detect a CPU with a lot of cores.
   
2. Open Process Lasso. Don't freak out with the UI, what we're doing will be very simple. Go to OPTIONS/CPU/CPU AFFINITIES...
   
   
3. Next we're going to designate cores for Dead Space to use. Dead Space only needs 2-4 cores to run properly. In the "Process match:" section, enter "dead space.exe" (without quotation marks). In "CPU affinity:" section, enter the cores you wish to assign.
   
4. For basic users, enter 0-1 (this assigns core 0 & 1 to the process) or 0-3 (this assigns cores 0,1,2,3 to the process).
   
   
5. For more advanced users, you can locate your fastest cores using software, such as HWiNFO64[www.hwinfo.com]. I can see that my fastest cores are 4 & 5, so I will assign cores 4,5,6,7 to the process, using the same process as described in step #3. This will allow Dead Space to access my 2 fastest cores, and 2 additional cores.
   
   
6. Hit "Add rule" and then "OK".

NOTE: You will have to have Process Lasso running in order for this change to persist. Process Lasso can run in the background, it uses next to no CPU power, and barely any RAM (~5-15 MB). It's worth just letting it persist in the background.

Now try launching the game. If it is still returning an error, repeat the first set of instructions but with Windows Vista instead of Windows 7. Windows 7 worked for me, I've read that some people have needed to run it in compatibility mode with Windows Vista.

This is how I was able to get the game up and running.

I highly recommend disabling mouse acceleration in this game. Check out this guide for more information regarding this:
https://gtm.steamproxy.vip/sharedfiles/filedetails/?id=463152850
Alternatively, this file will also fix mouse acceleration unless the player is walking on ground with flesh growing on it:
https://community.pcgamingwiki.com/files/file/840-dead-space-mouse-fix/

Also note: running this game at over 60 fps can cause physics glitches. I'm talking G-mod style ragdolls and collision sounds. The game won't crash at 60+ fps, but the physics will bug out a bit.