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During the Second Aegis VII Incident, he was part of an emergency maintenance team of the USG Kellion that was sent to the USG Ishimura to investigate and handle the ship's mysterious communications failure. After his contact with Marker 3A resulted in him becoming a host for the Marker's codes, Isaac became stranded in space for a long period of time before he was found half-crazed by an Earth Government ship.
For the next three years, Isaac was held in an asylum on Titan Station and was diagnosed with a form of dementia resulting in haunting visions of his deceased girlfriend, Nicole Brennan, which taunted him throughout the incident. His mind was harvested for blueprints which EarthGov used to create Marker copies.