I haven't tried this yet, but thought of it yesterday.

Build:
Ghostwalker, Shadowstep, Lone Wolf (doesn't really matter up to here), Hunter's instincts, Shadowstrike, Conceal( or whatever you like), Implacable, (whatever you like)
Pistol perks:
Lightning hands, Quickdraw, Fanfire

Basic dmg 2.5, flanked 4.5 +15% on crit, so theoretically +0.15dmg on average
If we go Lightning hands, into quickdraw, into fanfire, we get off 5 shots, meaning 23.5dmg.
If we can get our hands on the updated Shadowkeeper, we get 34 and 44,75 dmg.
This would struggle against armor though, because it reduces the damage of each shot.

This should kill any enemy, give us stealth and another action to run away. If we do this from stealth, we even get +65% crit on the first shot (which isn't that much of a deal though)

Holy cow....

Would this work? Or do I misunderstand how the perks work?