How can I reproduce it exactly?
Are they always active or only when the black hole is active?
How frequent are those flickers?
Has it happened with others mods before?

They always appear and flicker when I move. I turned off the mod and they were gone

Same for me. Constant black flickers the whole time even when I don't have the item.

I guess is some kind of graphic card compatibility stuff, as I can't reproduce the glitches it is really hard for me to find a solution.

It's very hard to replicate. I tried purpousfylly several times and couldn't get those black flickers, but they are there. I'm not a madman. They can appear at random during a run and will distract you very badly; it also sometimes hurts your eyes. It could be a weird black oval shape in the corner of the screen, or the whole screen will start to flicker black. Funnyly enough, in recording you cant see times when the whole screen begins to flicker, but you can still see small black glitches

It works on its own but when I turn on EID mod those black things starts to appear

https://steamusercontent-a.akamaihd.net/ugc/2431473966675570945/5141D8C1D99467DD80DBF08841317941B8515981/

I tried with only this mod and the artifices appear.
this only seems to occur in full screen