Don't be intimidated by the high number on High Roller's villain card: he doesn't start out with nearly that much HP.

Legacy normally fits nicely into just about any team, but combining his damage boosters with Tripwire or Sirocco's self-damaging effects is asking for trouble.

On the other hand, combining Next Evolution with Lead From the Front to negate all incoming projectile damage will make Tombstone and his posse absolutely miserable.

That's all I got for now.

Lao Feng: keep Judgment moving as much as possible in order to maximize damage to enemies and help allies.

Kain's main Power can keep Gloomweaver's Cultists from rising again as Zombies by sending all the Zombie cards back to his deck instead.

Hexterminator: Bringing along someone who can mitigate all the toxic damage you'll be receiving (Like Legacy's Lead FTF/Next Evo combo) definitely helps. Once Hex flips you might find it easier to win by helping him defeat all the rat people.

Blockbuster: Bring along some good healers, you're in for a long one. A smaller team might be more to your advantage. Be sure to include one or more heroes who can destroy villain ongoing cards, or Creative Control will make you miserable. Save a chuckle for his defeat screen.

So Inari has a rather easy infinite, Fleet-Footed Fox and Outfox can be looped indefinitely. Fleet lets you deal damage draw a card and play a card, Outfox lets you play the top card of you're discard by having an empty deck or a deck of just Outfox you can you Fleet to deal damage, draw Outfox then play outfox then have Outfox play Fleet-Footed to play your other copy of Outfox, the combo then ends letting the first copy of Outfox shuffle itself and Fleet-Footed Fox resolve to the discard then since it is still the end of you're play phase you can resolve the Outfox in play to continue the loop.

Scrat's Scrap cards work beautifully with Unity's power. Whenever you want to reap the benefits of destroying one, have her turn it into a Mechanical Golem.