A lot of the mods in this collection are only visual changes to the game,
(e.g., Portrait Mods, Ship Set Mods, Worm Hole Mod, Planet graphics, ASB, Battle debris, Camera views, UI, Cities, Rooms, Name List, Flag Emblems, Fleet Formation Mod or any fleet formation changing type mods you choose to use).

The mods that change game mechanics may require all DLC or specific DLC.

The following list is the mods that indicate in their descriptions that they interact with specific DLC:

Extra Ship Components NEXT does not explicitly require you to have any of the DLCs, but some content (primarily, leviathan rewards) will not be available unless you have the Leviathans DLC active

Recommended DLC, but not required: Leviathans. The Living Planet Space Monster does require the Leviathans DLC. (Per the Author this is probably not an issue).

Recommended DLC, but not required: Ancient Relics, Utopia, Synthetic Dawn, Nemesis and First Contact . (Having these DLC when using this mod will provide additional rewards).

Recommended DLC, but not required: Ancient Relics, Utopia, Synthetic Dawn, Nemesis and First Contact.

Recommended DLC, but not required: The Machine Age, Synthetic Dawn
(Machine will be only available if you (or the host) own The Machine Age or Synthetic Dawn DLC).