Using absorbents or guardians to take all of the damage for your group, frenzy or banshee to boost damage output, siren/gorgon/mythical or even cursed variant for CC, disruptors to prevent bosses from using active abilities and to remove lucky variants dodge chance, element variant to remove lucky DR and cause ability prevention, armor break buff to help bypass Armored variant DR, reflect to counter cosmic group gods and Apocalypse, Midas touch to turn bosses to gold and increase their damage taken, ability prevention debuffs to stop mythical heals, inversion to greatly increase damage to summoners, absorbent/guardian Meks to deal with torpor of taming/utility gods, affinity medallions to boost the stats of your tames, or any of the nearly 250 unique/legendary saddles to change the battle strategies entirely through hundreds of thousands of unique combos.

Or, you could just join the Discord and get help with whatever you're specifically struggling with....