Did some performance tests and here are my numbers:

Rig
CPU: Intel Core i7-6700K @ 4.4GHz
RAM: 32GB
GPU: NVIDIA GeForce GTX 1070

Versions
Game: 1.10.1-f2
Mod: 1.0.5 - all items enabled & hide items below treshold off (to test worst case scenario)

FPS
New Game @ Grand River - No Workshop - Population 0
Clean 121fps
Stats 110fps

New Game @ Grand River - No Workshop - Population 0 - Unlock All
Clean 100fps
Stats 90fps

Vanilla Map https://gtm.steamproxy.vip/sharedfiles/filedetails/?id=694214864 - No Workshop - Population ~280k
Clean 48fps
Stats 46fps