For those curious about what the six STD's are of the game and their effects, I've created the below guide so you can check them off the list as you send your girls into the sleaziest parts of town either for a quick buck or solely for the achievement.

Also, if a girl catches an STD, she can no longer go to the sleezy part of town until the STD is cured (if possible), no matter what items you may have equipped to her.

Note that if you still want to sleeze without risk, you can equip the girl with a 'condom' item from the Adult Store to prevent all STDs, but it is a one-use only item.

These STDs can be cured with the item 'Antibiotics' from the Adult Store, but must take up one of the girls' inventory slots for 3 days

Gonorrhea - prevents gain to any style or talent (no shopping or pole dancing)

Hepatitis - makes the girl too embarrassed to do cam shows

Chlamydia - girl will become stressed twice as fast

Syphilis - girl will become too embarrassed to do photo shoots

These STD's are completely uncurable, meaning that you should switch out the girl for someone else as they become entirely useless. The effects can be bypassed with the 'Steroids' item from the Adult store, but it only lasts for 2 days.

Herpes - causes girl to only earn half as much cash and half as many fans from all sources.

AIDS - The real killer. Any girl who catches this will be too depressed to do ANYTHING.