First of all, let's talk about Antialiasing:
-This is not your everyday AA settings, because it actually downsample your resolution at highest settings. Unless you got a powerful GPU, avoid this one or stick to the LOW setting, or even better, force antialising throughout the GPU control panel (i suggest Fxaa on Nvidia).
-Highest in-game AA = High GPU Usage = High temps\BAD framerate\Blurred faces
-Forced FXAA = Low GPU Usage = Low temps\30 FPS all the time!\Normal faces
Here's an example:

-NORMAL IN GAME AA

-FXAA FROM NVIDIA CONTROL PANEL

Shadow:
-There's a good difference between High Quality and Normal; i didn't notice performance drops with max setting, but GPU usage will ramp up a lot! In my opinion, stick to normal: It's hard to tell the difference during gameplay and you'll save some power.

Texture:
-Normal ALL the time. Please, DO NOT select low quality...

Motion Blur:
-Normal should be your main target, unless you want to puke all over the room...

Screen Space Shadow:
-Ambient Occlusion. Should be always active, it gives depth to ambience and shadows at nearly no cost in performance.

Local Reflection:
-It activates reflections on water and ground. Quite nice to see if you ask and not that heavy to process. ON!

Lens Flares:
-Or Bloom. This is a matter of tastes. If you don't like oversaturated lights, turn it off.

Depth of Field:
-This setting introduce the blur during cutscene, or at least, that's what i noticed. As for bloom, it's a matter of tastes. No performance hit at all!

That's all you need to know. The game works flawless at 1080p\Fullscreen.
Regarding some little issues:
-It seems that GSYNC may cause some problems (Low fps\choppy movies playback). Deactivate it and you're free to go!
-The game has been updated, so, no more black tabs on the launcher or the infamous "," in language settings thing!
-Remember, In game antialiasing will be your worst enemy! If you got really LOW fps, you know where to search!

I hope this guide will be useful to everyone!
By Squall811