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No. You want to lay down a straight path to the boss. Count how many turns (basically, how many squares you can move) until he attacks and see if you can get that chest/fountain, but make getting tot he boss BEFORE he attacks a priority. All timed bosses have a weakness that is only exploitable if you attack them (such as frail - all physical attacks do 1 extra damage).
If you let them attack you, you may or may not be any stronger than if you attack them (based on RNG loot tables, you could get the best equipment early or it could take a while, or you could never get it before the boss attacks). But if you attack first, you WILL get that distinct advantage.
Often, the best action to take is none at all: if you're not on one of the timed quests, then don't be afraid to discard the entire hand of cards you're given and skip that turn. Keep doing that until you get some cards you like.
In most dungeons, there is one Tier 1 monster that your chosen hero can beat more easily than others, so concentrate on fighting them as much as possible and take the time to exploit their weaknesses, e.g. build a block of rooms, then put a 'Night Owl' monster in the middle, or lay down a dead end and put a 'Loner' in it: mouse-over the bottom of the cards to get descriptions and tool tips about their strengths and weaknesses.