If you ever ran into issues related to incompatible version of Borderlands 4, or the game failing to write savegames, it is always because of Microsoft OneDrive.

If you have Microsoft OneDrive installed then you have to

Go to Windows Settings -> Updates & Security -> Virus & threat protection



Scroll down and select Manage ransomware protection

Allow an app through controlled folder access





In very bad setups you might need to launch the game's executable as administrator/in compatibility mode.

I recommend the free version of RevoUninstaller for getting rid of unwanted Windows feature like OneDrive and issues with apps in general, as its advanced options helps with leftover files and registry entries default uninstallers leave behind.

This is how my Windows 11 app list looks like after having unbloated Windows.



While you are at it, here are two more tips ~

a) you can use CCleaner to cleanup your registry, check for driver updates (the trick is: the free version does not download the driver updates for you, but you just need to know which you need to Google), and either use CCleaner or RevoUninstaller to check for unneeded autorun apps

b) if you have not done it yet consider using O&O ShutUp10++ as it helps not only with privacy but also can help with improving performance by disabling telemetry data



For each mentioned app you can use the free version available, also available as portable version (that means you do not need to install them). Stay away from scam websites which ask money for such tools.