First Blood
Easy, just kill your first human.


Upgrade: Complete
Again easy, buy a DNA upgrade from the DNA upgrades page of the lab.


Zombie Mk. II
This is done by crafting multiples of a zombie and then levelling them up.


Virus Efficiency
To do this, your first click that deploys virus needs to get 4 humans at once. If you want to do this early you can wait for a group of humans to stand very close together and then deploy the virus on them, however this achievement will come naturally when you upgrade your virus deployment method so there's no need to seek it out specifically.

The Second Amendment
This will happen naturally over time. As the humans deploy stronger counterattacks towards you, their forces will naturally take out some of your zombies and this number will eventually hit 500 without you having to do anything specific.

Urban Domination
Play a region over and over until the kill requirement changes to Kill em all. Play it one more time and the region will be destroyed.

Continental Domination
Destroy every region within one continent, and the continent is destroyed.


World Epidemic
This will just happen as you play. Areas adjacent to where you are will unlock gradually until you have zombies in every continent.

New High Score
To be honest I have no idea how score is calculated in this game but I got over 500k in my first game by just playing, so you shouldn't need to do anything special.

Zombie Intervention and Tactics
As you progress through the game, the humans will up their manpower against you until they eventually start deploying these units. You don't need to do anything to trigger this.

Giant Slayer
The bosses in Infectonator 3 become available after a certain amount of panic has been generated in a continent. Each continent has one boss, and the boss battle is the same as a regular level, but with more powerful enemies. The bosses can be defeated in any order, so it is easiest just to leave them until you are very powerful, and then defeat them via brute force. Please note that in order to defeat a boss, you must kill EVERY human in the level. If any humans survive the boss will not count as defeated, even if the boss enemy was killed.

The most annoying part of this game and the reason I'm making this guide is the random events and special zombie unlocks, so here's what I could figure out for you.

For the Watch, The Red Lady and Mother of Dragons
These three are random human NPCs that spawn in levels and must be killed. The spawn isn't guaranteed and there doesn't seem to be a fixed location where they appear. The easiest way to find them is to pick a part of Russia (I went for the big bit in the middle), then get it up to the large size. Once it's large, go into the level and see if the three spawned. If one has spawned, they all will, and their sprites stand very still and are fairly easy to notice. If they're there, play the level and kill them. If they aren't, close the game without saving and do it again until they appear.

Busted
These guys are the same as the Game of Thrones characters, they're random spawn NPCs. They appear in Kinsasha, Africa. Just repeatedly attack the city and close without saving until they appear, same technique as before.

The Downside Up
The Demogorgo is a powerful special zombie and I'd recommend trying to get it as soon as you can. Unfortunately it's irritating to get. To get the Demogorgo, you need to destroy a part of Asia, and it needs to have a certain layout that looks sort of like a lab/classroom thing. I got it by destroying Shanghai with this layout, but I've seen people say it can also appear in Seoul and Tokyo. To change which city is being attacked when you select a country, just click off of it and click it again and the city should change. The easiest way to do this is to pick either China or Japan, and destroy it. If you get the Demogorgo, great! If you don't, exit without saving and destroy it again. Repeat until you get it.

Amenhotep II
Unlocks automatically after you kill 100 humans in the Middle East


It Roams in the Snow
Unlocks after you kill 100 humans in snowy areas. Easiest to do in Russia.


Count Draculo
Unlocks after you kill 20 humans using specifically vampire zombies, which are unlocked through normal gameplay.


Lord Goben Giveth
Unlocks after you spend lots of money on support items and upgrades


Supreme Leader
Unlocked by destroying North Korea


Capitol Down
Unlocks when you defeat the Drumph boss


Disco Fever
Unlocked when you defeat the Justin Beaver boss


No One Can Hear You Scream
Unlocked naturally as you buy DNA upgrades

Second Win
Win twice. Done.


Anti-Zombie Drugs
Get far enough into a game that the cure starts being developed, then pop the game on 2x speed and go do something else until you lose.

No Virus Needed
When you enter a level, you don't actually have to deploy the virus. Instead you can click the red X on the bottom left and then use something else instead. For this achievement go into a level that is at least at the Large size, don't deploy virus and instead place zombies, or use canisters, burgers etc.

Panic at the Lab
Panic is cumulative across playthroughs, so just keep playing until the achievement pops. It took me two and a bit playthroughs to get it.

Toge News Subscriber
This achievement is technically grindy in the sense that you're going to have to play a LOT to get it. Opening the news tab at the bottom of the screen doesn't seem to count as watching the news, it only counts the news that happens at the end of a level. All you can do is play until it pops.

That's it! This game shouldn't take long to complete, the lengthiest times are the News achievement and the losing to the cure achievement. Please feel free to comment if there is anything missing or if you encounter any issues, and I will try my best to help :)