If you have read my 10K Damage on Floor 1 Guide, then this is very similar to it, with just slightly more gifts.
http://gtm.steamproxy.vip/sharedfiles/filedetails/?id=3453943155
The core is Spicebush Yisang who you can shard, and you need Lust Evade/Defense skills (e.g., Nelly Ryoshu & Neet Faust)--make sure they are Uptie 4 for the Defense Skill to have sin affinity.

Unlike last time, this one has more requirements for team which you can find below:
Only Meursault, Sinclair, & Gregor are flex slots

Here's a summary of what they all do as a collective:
1. Spicebush Yisang:
- core. Ideally, Lv. 50 or above.
2. Neet Faust:
- activate the Thorny Path passive
3. LCB Don Quixote:
- (5 Lust Owned) 1 ally with the most SP deals +10% Pierce damage
4. Nelly Ryoshu:
- (5 Pride Owned) When the ally that was deployed last wins a Clash, gain +1 Poise Count (3 times per turn), and gain 1 Haste next turn (once per turn)
5. Gamba Hong Lu:
- (5 Gluttony Owned) 1 ally with the most SP deals +20% damage with Heads Coins
6. Queequeg Heathcliff:
- (5 Envy Owned) 1 ally with the highest Max HP deals more Pierce Damage at less HP (Deal 0.3% more damage for every 1% missing HP (Max 30%))
7. Butler Ishmael:
- (5 Gloom Owned) When 1 ally with the fastest Speed attacks a target with Sinking, deal +1% more damage for every 1 Sinking on target (max 20%)
8. LBC Rodya:
- (5 Wrath Owned) 1 ally with the most HP deals +20% damage with Heads Coins
9. G Corp Outis:
- (4 Sloth Owned) 1 ally with the most HP randomly gains 1 Attack Power Up, 1 Defense Power Up, or 1 Protection at the start of the combat phase

With the team built, I will now run through the overall game plan:

Using the new mechanic of Starlight, this is, thankfully, every easy.

Start up the run with the following Grace of Immortal Star Buffs:
- Favor of the Nebulae++ (Identity levels, help with damage)
- Starlight Guidance++ (You want the 2 Damage Up)
- Perfected Possibility++ (You gain 3 Tier 3 gifts right off the bat which would be immensely helpful for the fusion we will be doing)

You could pick everything at ++ but it's expensive and I find it excessive. Prioritize those three because they give the most buffs in my opinion.

After picking the buffs, pick Barbed Lasso and Fluorescent Lamp.
Yes, but Barbed Lasso helps with building up Rupture just out of Lust Resonance (which we'll be doing a lot of)
And Fluorescent Lamp increases Damage if Abnormality part/s has/ve Rupture (up to 9 times)

Then using the Gift Search Function, get Thorny Path, Darkflame Smoking Pipe, and Sad Plushie.
Thorny Path is where you'll get most of your 99-99 Sinking out of.
Crazy Pierce Gift that is also Pride centered
Lets you deal up to 30% of extra damage based on SP.

Reaching Floor 1, roll for a "Automated Factory" theme pack, use "Pack Search" function if necessary. Play the floor until the boss. But when playing through the floor, please be mindful of the needed Sin resources for the aforementioned list of passives.
Lust & Sloth are not priorities because you can get them in the boss fight itself. You might also try and get Spicebush to 70% HP so you can maximize Queequeg Heath's passive.

In short, take every fight. Take harder fights if available because they yield more coins which you would need in shop.

When you reach the shop, upgrade Thorny Path, Barbed Lasso, and Fluorescent Lamp. Use the 3 Tier 4 Gifts to craft Artistic Sense which you would also upgrade it to max. I've tried this many times, I never fail to get it.

If you have more leeway, you could also consider these gifts.
- Pendant of Nostalgia (Tier 1 Poise): easy Poise generator
- Ornamental Horseshoe (Tier 1 Poise): easy Poise generator
- Emerald Elytra (Tier 1 Poise): easy Poise generator
- Punctured Memory (Tier 4 Pierce): +2 Base Power, +2 Clash Power, +30% Damage up on clash win
- Dueling Manual Book 3 (Tier 4 Pierce): +2 Clash Power, +2 Pierce Damage Up, +30% Damage up on clash win, cond. 0-3 Offense Lv. Up

Quit if the boss is "Clippity-cloppity? Tap Away!" You would want "You Want To Get Beat? Hurtily?"

Hold on, dear reader. There are a lot more other options in Floors 2, 3, and 4 that you can consider.
- anything with "Skin Prophet" boss
- anything with "You Want To Get Beat? Hurtily?" boss
- Tearful Things (Floor 3,4 on Hard, Floor 4,5 on Normal)
- Line 1: Madness (Floor 4,5 on Hard)
- Line 4 - Section #3 (Floor 5 and above on Hard)

It goes without saying that to be careful of what you choose when picking enemy buffs.

Back to our regular scheduled program:
If the Floor 1 boss is the one we want. The goal is to keep on evading/defending until enemies get 99/99 Sinking, your announcers would start idle chatting because it takes at least 35 turns to get to this point. then burst it with a lovely Sinking Deluge.
Honestly, you could just use Spicebush Yisang only and it would have a lot more damage because then, he got all the passives from other sinners.

Then finish the fight and you are done.

this thing isn't fun. Can we not see a 20K damage in one hit in the future? Thanks.