Locations are usually described using the names that appear on the in-game map. If you can’t find an area, look at the different map levels.

Everything is saved to your account as soon as it unlocks, you can exit missions or reload anytime and completed challenges will still be marked as such. Same goes for mastery level progression.

This doesn't include the challenges The Bells are Ringing, Get What You Wish For, Chameleon, or Discover Sapienza. The Bells are Ringing and Get What You Wish For require a custom contract. Here is a guide for all disguises:
https://gtm.steamproxy.vip/sharedfiles/filedetails/?id=3426333775

LOADOUT – Main Square with Fiber Wire & Lockpick


Can’t get spotted for “Weeding the Garden”.

Head to the car crash site, to the left of the starting location. Listen to the man’s phone call and start MS – The Good Son. This mission story will be completed later. Head back towards the starting location and enter the building to the right of the butcher shop (building #3). Enter the 2nd floor apartment in that building to get Safe House. Go through the back door of that apartment to get to the rooftop – this rooftop will be used a lot in future runs. From the rooftop, you can see 2 beach balls and 2 inflatable crocodiles on the beach in the distance. Shoot these 4 things for “Investigator” (2/6) and “Bend It Like 47” (2/4). Drop down to the landing on your right and enter that apartment. Shoot the beach ball right outside that apartment for “Bend It Like 47” (3/4). Exit that apartment through the living room door and enter the door right outside to the left. In that building, go downstairs and shoot the crocodile in the foyer for “Investigator” (3/6). Now go all the way downstairs until you exit the building and are at the beach square.

Head to the dock that is to the very left of the church. Shoot the last beach ball (in the water laying against the rocks) to get Bend It Like 47. Go into the beach sewers. There’s a crowbar near the entrance that can be used for pacifying the red plumber. When he isn’t looking, lockpick the gate and pacify him. Past the gate and to the right, shoot the crocodile for “Investigator” (4/6). Grab all 3 coins by the crocodile, they’ll be needed later. Go through the left hallway in the sewers to enter the catacombs. Go through the catacombs and enter the door to your right. Inside that room, take the priest disguise to get Man of the Cloth. Also destroy evidence from the camera recorder here.

Go upstairs to the church, while avoiding any enforcers. Listen to the conversation in the confessional and start MS – Absolution. Enter the morgue and hide in the coffin to get The Living Dead. It takes the lab technician a long time to get to the morgue so there’s some other stuff to do in the meantime. Exit the morgue and go to the building right across from it, the one with a green door (building #4). Enter the 2nd floor apartment in that building, a gardener should be exiting from it. In that apartment bathroom, shoot the crocodile for “Investigator” (5/6). Go back down to the beach square. To the right of the building you just left, there’s a man sleeping next to a table. Grab all 3 coins on that table, they’ll be needed later. Go back to the morgue and hide on the stretcher in the lab room. Wait until the lab technician is alone in this room.

When she’s alone, pacify her and take her biolab keycard to get Getting Access. Take the lab technician disguise from the corpse to get Grave Robber. Head back to the main square. Throw 5 coins into the main square fountain to get Luck Alone is Worthless. Go back to the alleyway you just came from and look for the flower shop. In case you aren’t a habitual savescummer, you should save here since we still need to be unspotted. There’s a couple standing outside the flower shop who will spot you if you try to lockpick the door. Go around to the flower shop’s side entrance and use the last coin to distract the male npc so he looks away. When he does, lockpick the door and enter the flower shop. During my video for this run, I did “Luck Alone is Worthless” first because a woman was about to walk inside the flower shop. Depending on your timing you might have better luck with the npcs. Take the delivery man disguise to get Special Delivery. Grab the flowers and continue with MS – The Good Son.

The guards at the mansion front gate frisk you, so you’ll have to go around them to keep your gun. Go back to the safe house rooftop and use the drop down on the left to enter the mansion grounds. Talk to the butler and follow him. Place flowers on Isabella’s grave to get MS – The Good Son. Silvio will soon walk down to the grave so wait until he is alone there. Kill him with fiber wire to get Piano Man. Dump his body in the nearby shredder and shred it to get Weeding the Garden. Continue with MS – Absolution. On the bridge to the ruins, there is a ledge on the right side. Drop down and shoot the last crocodile (underneath the pier in the distance) to get Investigator. Enter the biolab from the seaside entrance to get MS – Absolution // Underground.

Turn off the power to distract the nearby lab technician and take his disguise. Head to the main lab area. It’s easier to stay undetected here by using the ledge by the plane. Walk near the virus security terminal to start a conversation between two lab technicians. Let them finish then go up to the terminal. Read the biolab safety protocol and start MS – Hostile Environment. Take a hazmat suit disguise to get Hostile Environment. Enter the virus chamber to get MS – Hostile Environment. When inside the virus chamber, SAVE.

• Kill 3 npcs and dump their bodies in an acid container to get The Heisenberg & reload.

Cause distractions in the lab: sabotage the research station computer, override the robot arm (grab the two red samples), and turn on the ventilation system. This will cause all of the npcs to move away from the virus. While they’re distracted, increase the virus’ temperature to destroy it and get Eliminating the Competition. Whenever the virus is destroyed, Francesca will walk down to the lab if she is still alive. Go to the roof of the laboratory and wait for Francesca. When she is on the roof of the laboratory, SAVE.

• Francesca will eventually walk under a stalactite. Shoot it when she is underneath to get Caving In // Someone Could Hurt Themselves & reload.
  
  
• Kill Francesca with fiber wire to get The Personal Touch & reload.

Wait for Francesca to enter the virus chamber. When she is inside it, go to the virus security terminal. Turn off the ventilation system to kill Francesca and get Fatal Reaction. Exit mission.

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LOADOUT – Main Square with Lockpick & Coins


Head to the balcony right above the starting location (outside the ice cream shop). Listen to the man’s phone call and start MS – Catharsis. Right after the phone call ends, there will be a female npc wearing a pink top walking nearby. Bump into her a few times so she doesn’t spot you later while getting a waiter disguise. A waiter at the ice cream shop will eventually walk down to the alleyway, where he can be pacified. Grab the rat poison inside the ice cream shop and spike the therapist’s coffee with it. He’ll go to the bathrooms right below the ice cream shop to throw up, where another npc will be in the same stall. It’s easier to deal with that npc before the therapist gets there. Disguise as Dr. Lafayette to get Therapist 47.

Head to the mansion using the safe house rooftop (your gun is needed later) and talk to the butler. Enter Silvio’s bedroom to get MS – Catharsis. Sit down and wait for Silvio. When Silvio arrives and lays down on the couch, SAVE.

• Smother Silvio to get Silence of the Man & reload.
  
  
• Headshot Silvio to get .45 Therapy // Straight Shot & reload.

Wait for the therapy session to finish, it takes quite a while. After the therapy session, Silvio will go to Francesca and talk to her. Exit Silvio’s room from the bathroom. After exiting from the bathroom, there is a pipe around the left corner. Use that pipe to go to the attic. Look for where Silvio and Francesca are talking and drop a propane flask down the appropriate fireplace. Kill both of them with a fireplace explosion to get Pro Pain // I’m on Fire.

All challenges related to the virus have been covered, so future runs will skip that part. An easy way to get a biolab keycard is to get it off Francesca, she drops one when she dies. Destroy the virus & exit mission.

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LOADOUT – Main Square with Lockpick & Lethal Poison


Can’t get spotted for “Getting Your Hands Dirty”.

Head to the butcher shop (just to the right of the starting location). Listen to the conversation and start MS – First Day on the Job. This mission story will be completed later. Head to the hairdresser (down the alley to the right of the butcher shop). Listen to the conversation and start MS – A Case Most Peculiar. Once you find the detective, wake him up by turning the nearby radio on and off. When he wakes up, he’ll call Francesca and arrange to meet her on the pier. Listen to this phone call. While he makes his way towards the pier, continue with MS – First Day on the Job.

Head to the safe house rooftop. To the left, there’s a ledge to get to the above apartment. Take the kitchen staff disguise to get Employee of the Day. Meet with the chef and cook the sauce (note that you have to wait until the prompt says ‘cook sauce’). Spike Silvio’s spaghetti with lethal poison. Ring the lunch bell to get MS – First Day on the Job. Killing Silvio with lethal poison will get What’s Your Poison? // Tasteless, Traceless. Continue with MS – A Case Most Peculiar.

The detective should be at the well outside the church by now. He’ll eventually stop in the nearby bathrooms where you can easily pacify him. Disguise as the detective to get Private ♥♥♥♥. Head to the pier and meet Francesca to get MS – A Case Most Peculiar. Francesca will start walking to the alley and her bodyguards will turn the other way. Kill Francesca as the detective to get Getting Your Hands Dirty. Destroy the virus & exit mission.

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LOADOUT – ICA Safe House with Lockpick & Coins


Can’t get spotted for “Pipe Down” or “BBQ Season”.

Grab the explosive golf ball in the safe house kitchen. From the safe house rooftop, drop down into the mansion grounds. Climb into the fountain (right behind the front gate guards). Grab all 3 coins in the fountain, they will be for luring npcs when doing “Pipe Down”. Climb through the back of the fountain. Go straight and you’ll end up in a room with the green plumber. Pacify him, then take his disguise and lead pipe. Savescumming is recommended for this next part. Disguised as a plumber, pacify 10 npcs with the lead pipe (without getting spotted) to get Pipe Down. When that’s done, disguise as mansion security. Head upstairs and outside to the garden (where Silvio practices golf). Silvio is about to get killed in a bunch of different ways; this run is basically just bullying Silvio. When Silvio is about to walk onto the garden, SAVE.

• Place the explosive golf ball in the bucket. Kill Silvio with the explosive golf ball to get Tee Time & reload.

Head to the observatory roof. Wait for Silvio to go through his route (he will go from the garden->observatory->dining hall->fireplace->repeat). When he is about to enter the dining hall, SAVE.

• Shoot the dining hall chandelier when Silvio is underneath it to get Phantom of the Mansion & reload.

Wait for Silvio some more. When he approaches the fireplace, SAVE.

• Grab the nearby propane flask. Drop the propane down the fireplace when Silvio is next to it to get BBQ Season & reload.

The challenge description doesn’t say this, but “BBQ Season” only works for this fireplace. Which is why it did not work when Silvio was killed by the fireplace explosion in run 2. Francesca doesn’t have any challenges related to her this run, so she can die using any method. If you did not know, there is a very easy way to stealthily kill her using the secret virus prototype. Go to Silvio’s bedroom and go into the room that is to the right of his fireplace. There is a model ship in this room. Shoot it to get the virus prototype. Throw the virus prototype somewhere in Francesca’s vicinity to kill her.

Head to Mother Caruso’s bedroom. Read the medical journal and start MS – Beyond the Grave. Turn on the gramophone to get Anybody There. Lure Silvio back to Mother Caruso’s bedroom. After ringing the service bell, make sure to turn on the fan by the rocking chair. Otherwise, Silvio will flee. Wait for Silvio to enter the room to get MS – Beyond the Grave. Kill Silvio. Destroy the virus & exit mission.

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LOADOUT – Undercover in Mansion Kitchen with Emetic Poison & Lethal Poison


Talk to the chef to start his dialog. Head to the back of the kitchen. Go into the room to your left and grab a can of expired spaghetti sauce. Grab the rat poison on the kitchen counter. Cook the sauce and spike it with the can of expired spaghetti sauce. Ring the bell to call Silvio to eat. Go into the window that’s across from the dinner bell (there is a camera right above it) to enter Francesca’s bedroom. Read the romantic note and start MS – By Candlelight.

Exit Francesca’s bedroom and go around to the backyard of the mansion. Spike the water bottle on the table by the pool with rat poison to make the golf coach sick. Listen to the golf coach’s phone call. Now it’s just waiting on Silvio and the golf coach to get sick. When Silvio gets sick, he will walk to the cliff just to the left of where he eats. Push Silvio off the cliff to get Cliff Diving. The golf coach should be just finishing throwing up, go back to Francesca’s bedroom and pacify him. Disguise as the golf coach to get Lover Boy. Dump his body in the bathroom cabinet for “Love Triangle”. Call Francesca and wait for her to arrive. Sit down as the golf coach to get MS – By Candlelight. When she is outside the room (not too close to the door as we need enough time to poison her champagne), SAVE.

• Kill Francesca with lethal poison to get A Poisonous Vintage & reload.

Spike Francesca’s champagne with emetic poison. Drown Francesca to get My Name is Hurl // Hold My Hair // Versatile Assassin. Dump her body in the bathroom cabinet to get Love Triangle. Destroy the virus & exit mission.

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LOADOUT – Undercover as Security Staff with Lockpick & Coins


Head inside to your right and grab the screwdriver on the table. Head to Francesca’s office and enter the door to the right of her desk. Grab the safe combination inside that room. Head back to the outdoor patio where you started and go up the stairs to the attic. Listen to the conversation and start MS – Memento. After the guards finish talking, pacify both of them so it’ll be easier to walk around downstairs later. Open the safe and find the DNA sample to get You Crack Me Up. Head back downstairs to the outdoor patio. Tamper with the wire plug and turn on the nearby faucet. Turn off the faucet right after so it doesn't create a distraction later. Francesca will eventually walk into this trap. Electrocuting Francesca will get Shocking!. Give Francesca the DNA sample to get MS – Memento.

Head downstairs to the balcony that connects the mansion and the observatory (located on level 5 on the map). Listen to the conversation and start MS – Memory Lane. Find the VHS tape to get A Family Affair. Play the VHS tape and grab the amputation knife. Hide as the plague doctor to get MS – Memory Lane. When Silvio is alone in front of you, SAVE.

• Subdue Silvio (do not kill him) and drag his body underneath the solar system display. Shoot down the display to get Bring Down the Sky. Kill 3 guards with the amputation knife to get Surgical Procedure & reload.

Kill Silvio with the amputation knife to get Plague-iarism. Destroy the virus & exit mission.

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LOADOUT – At the Harbor with Remote Explosive & Any Explosive


I used napoleon blownaparte, but you can use any explosive item for this run.

Head across the beach and go into the alleyways. There is a breakable wall in the corner that leads to the biolab. Throw your explosive item at the wall to break it. Breaking the wall now will save us from having to wait with nothing to do later because a guard from the lab will investigate the area after the explosion. Head to where the detective is and wake him up. You don’t need to listen to his phone call, we just need Francesca to start walking to the pier for “Walk the Plank”. Head back to the breakable wall and enter the biolab. Go upstairs to your right when you enter. There is a lone guard up there, pacify him and take his biolab security disguise. In that same area, there is a climbable pipe towards the edge that is surrounded by miscellaneous lab items. Drop the remote explosive by these items for “Error Plane” – refer to the video for an exact location. That area is where Silvio will go when in lockdown.

Head to the ruins. Go upstairs where the cannons are located. The cannon furthest to the right (facing the mansion backyard garden) is where we’ll start. Grab the cannonball and gun powder laying by the cannon. When Silvio is at the garden, SAVE.

• Load and fire the cannon at Silvio to get Bogey & reload.

At this time Francesca should be fairly close to the pier. Wait until she is on the boardwalk. When she is, shoot Silvio (do not kill him) to make him go in lockdown. Go to the cannon that is facing the pier. Load and fire the cannon at Francesca to get Walk the Plank. Grab the cannonball and gun powder by the last cannon (facing the island). Guards will soon be investigating the area and Silvio will be running to the lockdown location. Hide from the guards and watch Silvio. Once he’s standing still, detonate the remote explosive to get Fly, Silvio!.

Silvio will now try to escape on his plane. When the guards have left the area, load the last cannon. Wait for Silvio to start flying his plane. When the timer is at 00:20, be ready to fire the cannon. Fire it when the plane is aligned with the cannon, in the middle of the screen. Shoot down Silvio’s plane to get Error Plane. Destroy the virus & exit mission – and you won’t be able to exit in the plane this time!

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LOADOUT – At the Harbor with Silenced Sniper Rifle in Briefcase & Any Explosive


A silenced sniper rifle is needed for “Sniper Assassin”. You can use any explosive item. I used a briefcase for this run (unlocked at Miami mastery level 10), but if you don’t have that yet you can stash the sniper rifle in the sewers (unlocked at Sapienza mastery level 17).

Shoot the electrical box outside of the observatory to get Watch the Skies. The observatory will start opening. Head to the breakable wall and throw your explosive item at it. Head to the bathrooms that are to the right of the church and grab a coin. Head inside the church and wait by the back of the church, behind the altar. That staircase leads to the church tower. Wait until the church members pass, one will be walking downstairs and another will soon enter the room. When the one walking downstairs has left, distract the other one with the coin and head to the top. Silvio should be at the observatory by now and looking into the telescope. When you get to the top of the church tower, SAVE.

• Shoot the telescope glass to get An Eye for an Eye & reload.

Unfortunately, “An Eye for an Eye” does not count towards sniper assassin, the game doesn’t count it as sniping Silvio. By this time, Francesca should be visible from a window. Snipe Francesca to get I Aim to Please. Wait until Silvio walks outside the observatory and snipe him. Even though you will get red guns (because the bodies were found), the long distance makes it so the guards are only alerted to the location of the shots. “Sniper Assassin” should still work as long as you aren’t compromised. Destroy the virus & exit mission to get Sniper Assassin.

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LOADOUT – Main Square Tower with Remote Audio Distraction & Explosive Baseball & Silenced Sniper Rifle Stashed at Ruins


The explosive baseball (unlocked at Whittleton Creek mastery level 10) is needed for “Sapienza Sports Club”. Also, this screenshot location is wrong, make sure to start at the main square tower.

Turn around and grab the lead pipe. Head downstairs one story. Go out to the balcony and head upstairs to the hippie’s apartment. Throw the lead pipe at him and grab the first joint on his table by the window. Go all the way downstairs and head to the safe house. Grab the explosive golf ball and take the free mansion security disguise at the adjacent apartment. Head to the mansion backyard. There is a pathway behind the pool that leads to the ruins. Go across the bridge to the ruins while avoiding the guards.

Go to the right to go around to the back entrance of the ruins. A guard will soon be walking towards this gate. He waits at the back entrance for a while so throw the noise distraction at him to save time. From the back entrance, go up the stairs on your right, then go down the stairs to your left. Drop down the ledge and grab the second joint. Go back to the main area of the tower and pick up your stashed briefcase. Return to the mansion backyard. Throw the briefcase so it lands on the balcony above this area (with the black iron railing). Place a joint by the fireplace. Pacifying Silvio with a joint will get Double Jointed. Head up to the area where Francesca stays. In the big room with the fireplace, place the other joint here (prompt is on top of some boxes). Pacifying Francesca with a joint will get One Hit Wonder.

Head to Francesca’s office and go out onto the observatory roof. Grab the crowbar laying by the roofing supplies. Drop down onto the balcony with the black railing and retrieve the sniper rifle from the briefcase. In the ocean, there is a ship with 4 bells attached to it. Shoot these bells in order (left, right, top, bottom) to get Unleash the Kraken. Head back to the big room where Francesca is and wait for her to smoke the joint. There is a guard who waits by the nearby outdoor seating area. Throw the crowbar at him when the coast is clear so he’s out of the way.

After Francesca is pacified, throw the explosive golf ball at her for “Sapienza Sports Club”. If you throw it from outside the room at an angle, you can do it without getting spotted. Head over to the roof overlooking the mansion backyard. Silvio should have also been pacified by now. Throw the explosive baseball at him to get Sapienza Sports Club. Destroy the virus & exit mission.

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