Resident Evil 0 is a prequel to the original Resident Evil, putting you in control of both Rebecca Chambers and Billy Coen. With no item boxes and a unique partner system, this game plays differently than other entries in the series.

This guide covers:
• Character switching
• Inventory and item strategy
• Puzzle help
• Boss tips
• Weapon recommendations

• You control 2 characters: Rebecca and Billy. You can swap freely or control both.
• Rebecca: Can mix herbs and chemicals, but is weak in combat.
• Billy: Stronger, takes less damage, but cannot mix herbs.

Tips:
✔️ Use Rebecca for support and item mixing.
✔️ Let Billy take the lead in combat-heavy areas.
✔️ Use “Solo” or “Team” mode wisely to solve puzzles or split tasks.

• There are no item boxes. You drop items on the ground and return for them later.
• Use the map: Dropped items appear on the map for easy backtracking.
• Designate rooms for item drops: Like “supply stations” — pick central spots.

Item Priority:
✔️ Save ammo — especially for Shotgun and Grenade Launcher
✔️ Always carry at least one healing item
✔️ Don’t hoard too many key items — focus on puzzle progression

• Handguns: Standard, decent. Billy’s has more stopping power.
• Shotgun: Powerful and spread-based — save ammo for tough encounters.
• Grenade Launcher: Found later, essential for bosses.
• Molotov Cocktails: Very effective against Leech enemies. Craft with bottles + gas.

Tip: Use Billy for most shooting, and keep Rebecca safe in backup roles.

• Watch your surroundings: Examine objects, notes, and rooms carefully.
• Some puzzles are co-op based: Use character switching to operate levers or pressure plates.
• Chemical mixing: Rebecca can collect red and green chemicals in her mixing kit. Useful for several puzzles and healing.

Key Puzzle Reminder: You’ll need the Hookshot multiple times — don’t leave it too far behind!

• Zombies: Standard fare. Headshots or Shotgun when grouped.
• Leech Zombies: Molotovs or Grenades only — don't waste handgun ammo.
• Crows/Frogs/Bats: Avoid if possible. Use shotgun or handgun in tight spots.
• Bosses:
 - Scorpion (Train): Use shotgun.
 - Centipede (Church): Attack fast to save hostage.
 - Leech Queen: Final boss. Grenades or magnum, play defensively.

Pro tip: Don’t be afraid to flee if overwhelmed — especially in tight hallways.

• Use Ink Ribbons wisely: Save at major milestones — before puzzles or bosses.
• Mix herbs often: Combine Green + Red or triple Greens to save space.
• Use healing between characters: Billy can’t mix, but he can use what Rebecca mixes.
• Manage caution/danger status: Yellow caution is usually fine — red danger means heal ASAP.

Resident Evil 0 can be brutal at first — limited space, tricky enemies, and a unique system — but with a little planning, it becomes one of the most strategic RE games. Master the partner system, think before you shoot, and keep your inventory tidy.

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