Here are some general tips to make your permadeath run easier:

- Select per act option instead of whole game
- Drive carefully
- Save often (You only have one manual save and auto-save)
- Heal quickly after injury
- If you get into trouble, pause and load back to previous save
- Stay away from explosive barrels (Enemies will shoot at them if you're too close)
- Do not underestimate wildlife
- Be cautious of enemies with heavy armor carrying heavy machine guns
- Prioritize health upgrades first when doing Nero checkpoints

As a rule of thumb, be vigilant of all the hazards around you. In the very first act alone, I died 5 times making stupid mistakes like driving off a cliff or hitting a tree.

In Act 1, there are no checkpoints until the mission marking the beginning of Act 2:

No one Saw It Coming

To play it safe, do one more mission after this listed one to ensure you get the checkpoint. Equip Sarah's fuel tank that you obtain from completing the target scores of all four maps in Horde Assault. In the mission where you go to your first Nero checkpoint, get the health upgrade. I recommend putting a few points into health before anything else.

Additionally, I would give Leon's drug stash to Tucker so that you can quickly get the MWS assault rifle at lvl 2 trust.

In Act 2, I found two additional checkpoints in the missions:

You Could Have Done More
Why Am I Here

As always, please complete one more mission after these listed ones to make sure you clock the checkpoint.

For Lost Lake Camp, quickly get level 1 trust so that you can buy the C8 rifle, a very powerful sniper. This weapon comes in handy in a lot of combat situations, especially when you face off against the first breaker of the game in the mission Playing All Night.

In the final boss fight against Carlos, make sure to dodge, hit once, and repeat. I had to restart this long mission for being low on health, from attempting to land more hits.

In Act 3, I found two checkpoint in the missions:

Riding Nomad Again
This Could Be It

Prioritize getting lvl 2 with Wizard Island. You can acquire the Chicago Chopper and RPD, the only two weapons you need to breeze through the rest of the game.

I received the final checkpoint in the mission

Ascending From The Underworld

Everything in this mission and after is pure combat(taking down hordes and fighting militia). In these final missions, I encountered a lot of heavy armored enemies that can shred through your health quickly. Always shoot from cover when dealing with them.

In the finale where you attack Wizard Island, equip the C8 rifle that I recommended earlier. When you go up the mountain, enemies tend to throw a lot of grenades that can result in instant death. With a reliable sniper, you can keep your distance. In general, I would progress through this mission slowly because of the amount of enemies.

In the fight against Skizzo, it is scripted for you to be low on health when he shoots the explosive barrels. Simply wait for the fire on the right side to clear and roll to it. Wait for Skizzo to stop firing and roll to the metal box that is closest to him. After that, do the final roll towards him.

The permadeath achievement is very obtainable if you put the time and effort. As long as you guys follow the general tips in beginning of the guide, your margin of error will significantly reduce.

Please let me know about any questions or concerns in the comments below. I will try my best to get back to you ASAP.