All achievements are missable.
There's also no chapter select so missed achievements will require a new playthrough.
None of the achievements are difficult and most of them are self-explanatory.

Saves are located in:
%userprofile%\AppData\LocalLow\Ubik Studios\Leila\

• Clear Your Mind -- Sweep all the leaves from the forest
  
• Fidgety Mind -- Interact with the forest 120 times

The forest acts as a hub for the game's various sections. You also start in the forest.
These two achievements can be unlocked from the very start, simply run from one end to the other clearing all the leaves and interacting with things.
You don't need to clean all the leaves, I had a few piles leftover and the achievement still unlocked.

• Close Call -- Complete with one light bulb left

This is the hidden object puzzle where you have to find the four projector parts.
There are hanging light bulbs in the background which act as lives before the puzzle resets. Find everything with only one light bulb remaining.

• Best-Seller Factory -- Try all the possible scenarios

When you get to the section on the laptop in the cafe, you have to use four ideas to create a story summary.
Drag all possible combinations onto the book in the middle.
There's 4 items in the first group, and 2 items in the other tree, making 32 combinations in total.

• Score! -- Throw the paper in the trash

After "unplugging" the bedroom, throw the paper on the floor into the trash can.

• Wisdom Uploaded -- Listen all the quotes from Aurelius

Immediately after above, click on the bust in the bookshelf and run through all its quotes.

• Pi is a Lie! -- Enter the Pi as password

When prompted to enter a password to log in to the PC, enter 3141.

• Mined the Game -- Beat the mine field

Play the minsweeper game on the PC and finish a level.

• Congratulations! You Won a Fake Lottery! -- Open the scam e-mail

When browsing the Roman history page, you'll get a new email notification. Don't do anything else and open the email and click on the link.

• Tower Conqueror -- Complete the Hanoi chapter with fewer moves

In the section with the three puzzles to repair the robot, one of them is a four-part Tower of Hanoi puzzle. Complete it in under 45 steps.

39-step solution:
Part 1 (7 steps)
1->3  1->2  3->2  1->3  2->1  2->3  1->3

Part 2 (8 steps)
1->3  1->2  3->2  1->3  2->1  2->3  1->2  2->3

Part 3 (7 steps)
1->3  1->4  4->5  1->4  4->6  5->6  3->6

Part 4 (14 steps)
1->2  1->3  3->4  2->3  3->4
1->2  1->3  2->1  1->3
4->3  3->2  4->2  2->1  1->3

• Swing It! -- Swing the tire

Simple achievement. When repairing the treehouse, repairing the ladder also repairs the tyre swing. Play with it before repairing anything else.

• Oops! -- Drop the laundry

When you need to hang the clean laundry in the bathroom, unfold the clothesline, hang the laundry, then fold the clothesline, causing all the laundry to fall.

• Optimization Freak -- Completely empty a shelf in the fridge

When tasked with putting the red pot in the fridge, rearrange all the things in the fridge and clear up an entire shelf. Do it before putting the red pot in the fridge.

Achievement timestamps in video description.