First of all be sure in correct installation, for this find Microsoft Visual C++ 2010 x86 and Microsoft Visual C++ 2010 x64, remove them if present, uninstall game, install game again and if game doesn't find library, it will be installed by steam, then will be installed game and it's correct order of installation.

If this library wasn't installed at all, game will throw modal window with warning to install manually, but better to repeat sequence above, in this case will be installed correct version of library.

In most cases of launch crashing, exist 2 ways to find a reason:

1. In logs placed in game directory C:\Users\User\Documents\Almost Human\Legend of Grimrock 2 or in \Steam\steamapps\common\Legend of Grimrock 2
   
2. In Event Viewer Logs, to navigate it in windows, press Win + R and run eventvwr.exe

In first case if you have no idea what crashes your game, and you have this log, post content of this log on official forum in branch https://www.grimrock.net/forum/viewforum.php?f=21

In second case navigate to Event Viewer Logs -> Windows Logs -> Application and there will be records of crash.

If game doesn't launch at all and in Event Viewer Logs you found record with the reason of crash of Kernalbase.dll, then quickest way to solve it is to create a new Operating System User and run LoG with this User.

Sometimes game launches well, but when try to save, files don't creating, usually it happens by the reason of strict policies of OS and run game with privileges of administrator solve it.

The main reason of it in out of memory and usually happens when game heavily modded, could be solved with decreasing level of textures quality or another parameters of graphic quality.