It's simple: shoot the tires to prevent them from escaping and shoot the weapon to disarm it. However, it's not as straightforward as it seems. Each block has an armor stat, which means that some blocks are easier to break than others. The stats of the tires and weapons are very high, while normal blocks aren't. But if you break the block underneath the weapons or tires, they will fall off. So, in conclusion, try to shoot under the tires and weapons to destroy enemies more easily.