This guide has merged with my other guide, Saints Row 2: The Purgatory Guide. If you want the definitive SR2 experience, check it out.
https://gtm.steamproxy.vip/sharedfiles/filedetails/?id=3148058457

A couple months ago while I was trying to play Co-op with a friend, I noticed that Openspy wasn't working anymore. I could see their game, but I couldn't connect to it. This went for everyone else I tried playing with, until I decided to bite the bullet and install Radmin VPN. Recently, I tried playing with a friend again, but we had issues while using Radmin. Eventually I said screw it, and did some research in the Openspy discord server. To my surprise, I found a solution.

IMPORTANT: For this to work, you must use a modded executable. This one adds Openspy compatibility and doubles the amount of virtual memory the game can use, which is required if you are using DXVK. It can be found here[drive.google.com] or here.[mega.nz]

1. Download Openspy from Here[github.com].
   
2. Extract and open the zip file. (I personally use 7-Zip, but the Windows built in "Extract All" tool should work fine.)
   
3. Take "openspy.x86.dll" and throw it into your Saints Row 2 folder, then rename it to "dinput8.dll".
   
4. Boot up Saints Row 2, go to Co-op, online, and select create account.
   
5. Create an openspy account, make sure the email address ends with "@openspy.net".
   
6. Once you've made it, log in. (The game will save your info, you will just need to log in when you want to play Co-op/Multiplayer)

If all goes well, you should be logged in.

Congratulations! Openspy is now up and running, you should be able to create and join games now. I tested Co-op with a friend and it worked great. Shoutout to user kebabstorm for making a much more detailed guide in the Openspy discord server. If you have any problems, I recommend going to the Openspy discord server for help, they know more about this ♥♥♥♥ than I ever will.