DO NOT start the game using the "PLAY NOW" button. It launches you into the live service campaign and will immediately bombard you with spoilers. Instead, choose "OPERATIONS" then start with the "REASSEMBLE" campaign.

1. Reassemble Campaign
   
2. Avengers Initiative part 1
   • Reigning Supreme Mission Chain (Replaced by Back in Action Mission Chain)
     
   • Heroic Mission Chains for the initial Avengers (can be done during Reassemble campaign)
     
   • HARM-related Missions
     
   • 1-time introductory Missions to Hubs, Vaults, Hives, etc.
     
   • Cloning Around Mission Chain (Introduction to Villain Sectors)
     
   • Tachyon Rifts introduction Mission Chain
3. Taking Aim Campaign
   
4. Future Imperfect Campaign
   
5. Avengers Initiative part 2
   • Back in Action Mission Chain
     
   • Rooskaya Protocols, Red Room Takeover, Tachyon Anomaly and Cosmic Events
     
   • Mighty Thor (Jane Foster) introduction
     
   • Beating the Odds Mission Chain (not just the Villain Sector)
     
   • Corrupted Vibranium Event
6. War for Wakanda Campaign
   
7. Avengers Initiative part 3
   • Back in Action Mission Chain final step
     
   • Discordant Sound Raid
     
   • No Rest for the Wicked Villain Sector
     
   • Cloning Labs OLT
     
   • Winter Soldier introduction and Heroic Mission chain

This guide is meant to help make sense of the sequence of events and DOES NOT serve as a recommendation on HOW you should play the game. It is difficult to play in the order shown past the Reassemble Campaign due to the live service nature of the game. The moment you enter the Avengers Initiative Campaign, whether accidentally or automatically, it will have characters you haven't met show up talking about things you haven't played through. The final bosses of the later campaigns and missions are also difficult without some leveling and gearing in Avengers Initiative.

Nick Fury's return was never detailed. The most we can infer from his introductory cutscene is that confiscating the Cosmic Cube from Monica somehow altered the timeline and allowed him to escape from AIM's custody.

Reigning Supreme was the introductory mission chain to the live service campaign, Avenger's Initiative. It was later replaced by Back In Action which added Nick Fury and Wakanda locations. These Missions should technically take place right after the Reassemble Campaign because both chains end with a cutscene of Ms Marvel being officially inducted into the Avengers, with Clint and Kate still absent. Back In Action complicates the timing of this with the introduction of Nick Fury and Birnin Zana.

The 1-time Mission Chain involving this Villain Sector has a followup step at Ant Hill, with a cutscene that shows the Cosmic Cube being put into safekeeping and a small tease which amounts to nothing now that the game is discontinued.

The last panel of her cinematic slideshow has her hanging out with Kate and Clint, and she was pulled into this universe by the Tachyon Anomalies so all things point to her appearing after Future Imperfect but before Beating the Odds. However, this is contradicted by her absence in the War for Wakanda campaign.

There isn't really much story to these events and their missions are the same usual ones reused with added perks or objectives. They are still included in the list because they are caused by events of the campaigns.