curses are items that get added when you get them from an event or a battle where the enemy curses you.

they have negative effects but can be used to your advantage

for example the evil hand can destroy items for you and get rage and the matrioska can power it

curses can also work well with emerald circlet or cursed blade because those items do better with them

curses will follow you by replacing your item pool if you dont take them. for this reason, you may be looking for a way to delete them

luckily you can do that! with the power of lanterns you can cleanse them and that allows you to leave them behind

destroying them also lets you get rid of them forever, stuff like dynamite or clean burn can help with that.

evil glove, even though it is a curse, can destroy other curses