A list of the elements and their effectiveness against other elements can be found in the following table.

During Tower Testing, higher difficulty modes exaggerate the base strength or weakness by a certain factor. The formula for this interaction is:

(Eff / 100)Fac × 100

Where:

• Eff is the base effectiveness, as a percentage, found in the table above.
  
• Fac is the difficulty factor, found in the table below.

For example, Fire enemies would usually take 25% damage from nature attacks. On impossible difficulty, this damage would be reduced to just (25 / 100)8 × 100 = ~0.0015% damage.

On the other hand, if using water attacks, the fire enemies on impossible difficulty would instead take (200 / 100)8 × 100 = 25,600% damage.

In the New Round window, the elements of the selected region are shown like so
(Element colors labeled)