A few general pointers:

- The game works based on events. Usually, some sort of notification is triggered (new email, updating some info, message from Ana, therefore if you read through everything you'll be busy enough and the next event will trigger naturally when you're done with the current task. However, if you want to skip things, you'll have to wait a couple of minutes until the next event pops.

- Whenever you're stuck, you can ask Ana for "help". She will give you a nudge in the right direction, but will not tell you the solution. Try to solve things yourself and check this guide only if you really must, otherwise you will spoil the whole fun of the game.

- On the top right of the screen you can see the active line of investigation, which means that her answers / pointers will be referring to that. Feel free to switch to a different line of investigation by typing "I want to investigate...".

- For the achievement related to filling your contact list, you will have to input the name of the people to Ana so that she adds them to your contact list; some of them are automatically added when you receive an email from them, but others need to be "discovered" this way. The persons you meet (regardless of whether they are automatically added to your contact list or not) are marked with "👨‍🔬" in this guide, so whenever you see this icon, just post the name to Ana.

- Some cosmetic items can be unlocked only after certain steps in your playthrough; the passwords needed to unlock them can be found in the last section of this guide

- After the ending, you can still play and collect the missing cosmetics / contacts / evidence as long as you completed all the tasks before (otherwise some evidence entries will remain locked)

- Before attempting a second playthrough, make sure to:
- copy nanomax_systemConfig from \Acolyte_Data\acolyte_core\user\backup back to \Acolyte_Data
- delete the BAHandshakeBatch file from \Acolyte_Data and from the folder you extracted it to
- optional (for safety): right click the game in your library -> Properties -> Local files -> Verify integrity of game files

Read the article above the tasks list.

Ana > Please setup my Nanomail account
Wait for the timer to complete.

Ana > Let's take the personality test
Just follow her questions and answer whatever you like.
This will unlock one background (city / country) depending on what you picked.

🏆 //GETTING TO KNOW ME

Ask Ana questions to find out more about her.
Examples:
Ana > What is your favorite color?
Ana > What is your favorite food?
Ana > Do you prefer cats or dogs?
Ana > Do you like watching movies?
Ana > Do you have free will?

🏆 //GETTING TO KNOW YOU

👨‍🔬 Jennifer Khan (optional)
👨‍🔬 Grace Tyler (optional)
👨‍🔬 Nicholas Jackson (optional)
👨‍🔬 Roy -> Roy Gilby (mandatory; reference from Nicholas Jackson's email)

Keep talking to her until you see her glitch out.
When this happens (Error 51), don't immediately submit a bug. Instead, talk to Ana first and try to decipher the message she got.
However, submitting a bug now with Error 51 or not doesn't seem to affect the story.

The binary numbers (made of 0 and 1) represent the ASCII codes for letters.
Copy the text and use https://www.rapidtables.com/convert/number/binary-to-ascii.html to translate it.
Ana > REMEMBER THE AMICUS TRIALS
Allow her to dig more. Continue talking until the update rolls out.

🏆 //DILIGENT

(It autocompletes even if you don't submit a bug report)

👨‍🔬 Robert Ford (mandatory)
👨‍🔬 Shanon Bright (mandatory, her name appears when you inquire about Robert Ford)
👨‍🔬 Dev Prakash (mandatory)

Ana > Please write a haiku
Repeat two more times. Your rating can be anything (doesn't affect the story).

Search online for occurrences of Gwilym Cadwallader.
Ana > https://gwilymcadwallader.medium.com/the-cult-of-nightingale-secrets-in-silicon-valley-392f79efea11
Ana > Or, perhaps most worrying, the fact that Acolyte’s Lead Engineer — Beatrice Abbot — has been missing for the past seven months.

👨‍🔬 Danielle Holdway (optional)

Go to the Steam folder where the game is installed and delete "nanomax_systemConfig.text". You don't have to close the game in order to do that.
🏆 //JAILBREAK

Watch DEEP_THOUGHT's video.
Look at the note attacked to his screen.
Input the password into the Investigation Tracker (rightmost button with a magnifier icon)
The password is: found4t1on!
🏆 Password correct
🏆 //DEDICATED

Check the source page of http://nanomax.technology/staff (right click -> view page source)
Look for a section having style="display:none;" (Beatrice Abbot)
Ana > Beatrice is a specialist in Dynamic Neuro-Architecture, pioneering new techniques in brain
scanning and emulation.
Ana > Whole Brain Emulation
🏆 //EPIPHANY

Ana > Investigate the encrypted emails
Copy the text from the email that Ana sent you (subject: "Encrypted email found on server") and use https://cryptii.com to decode it.
Decode -> Ciphers: Vigenère cipher -> "amicus" as key
This is an email from Francis Webb addressed to Fiona Nightingale and which contains the new key.
Ana > PINOCCHIO
When she asks about who gains the most out of this:
Ana > Phillip Richards

👨‍🔬 Lisa Harding (optional)
👨‍🔬 Fiona Nightingale (optional)
👨‍🔬 Phillip Richards (optional)
👨‍🔬 John Harris (optional)
👨‍🔬 Terry Mansell (mandatory)

For one evidence entry, investigate Terry Mansell's death:
Ana > How did Terry Mansell die?
Ana > Why did Terry Mansell kill himself?

Ana > I'd like to investigate the photograph
The photo is available in the game's install folder, in Acolyte_Data\acolyte_core\investigation_assets
Check the metadata of the image with https://jimpl.com/ to find the coordinates and location.
51°43'00.2"N 0°08'03.6"E
Ana > Unit 12, Woodside Industrial Estate, Thornwood, Epping CM16 6LJ, United Kingdom

Check the notes written on the right side of the document from the "FW: Thornwood" email (Lisa and Phil's editing notes):
https://docs.google.com/document/d/1uLPDu3f-ZtXcqA3XDU_tvyPVs-WiFTdb/edit
Search for "Amicus Trials Nanomax" on Twitter
https://twitter.com/SubjectTw3lve/status/1502315189114392580
Ana > subjecttw3lve[at]gmail[dot]com

You receive the email from Grace that tells you to submit a bug with the tracker password.
You can ignore the email, with the result that Grace will be fired.
Or you can submit the password, as requested:
Ana > [submit bug] found4t1on!
Neither of the paths has an effect on the story progression, but you'll get to experience different secondary storylines.
If you don't submit the password, Grace ends up being fired.
If you submit the password, Jennifer Khan is fired.

Ana > I'd like to investigate the harassment campaign
The photo is available in the game's install folder, in \Acolyte_Data
Use https://incoherency.co.uk/image-steganography to unhide the image
Ana > Filman Rose - Eyes forever open

Upload the audio file from Acolyte_Data\acolyte_core\user\nanomax_server\audio to https://academo.org/demos/spectrum-analyzer/ and decode it
Ana > It is the responsibility of scientists to never suppress knowledge
(a quote by Carl Sagan)
Give Ana a few minutes to process the information, until she says "You need to see this" and launches the video.
Reply to Ana and wait for the next event to trigger: the email from Ann-Marie Clarke.

👨‍🔬 Ann-Marie Clarke (mandatory)
👨‍🔬 Daniel Tan (mandatory)

The email from Ann-Marie Clarke mentions that a blog exists but is not linked to the main page of the company.
However, you can still access it via http://nanomax.technology/blog
There we can find some information about Norman (also mentioned in the email "The Amicus Trials" or in the article "Fiona Nightingale in Cabled"). This is needed for one evidence entry:
Ana > Norman was a nematode
And there's also a person that doesn't appear anywhere else:
👨‍🔬 Michael Carnell (mandatory)

Use https://www.dcode.fr/rot-13-cipher to decipher ABJURER NOWHERE.txt located in Acolyte_Data/acolyte_core/user/nanomax_server/.ba/abbotB_dataCache/
Ana > Goodbyes are hard, but often illuminating.
Allow Ana to do the cross-reference.
Ana > Nanomax history
Wait for her to compile it.
Ana > research blue birds
Search on Twitter for "Ex initio omnia possunt inveniri" (= All things can be found from the beginning; reference from Beatrice's "Farewell" email + Twitter)
The result leads you to https://twitter.com/NanomaxLied with a Pastebin file from Dr. Abbot and a link to her main Twitter account https://twitter.com/babbot76
In this Pastebin file you'll find a clue for the cache password and the fact that she is a fan of Carl Sagan should lead you to the solution (namely, the password).
Password to unlock BAHandshakeBatch.exe: AnnDruyan
Once unlocked, move the file to Acolyte_Data folder. Right after it's moved, Ana will start processing it.
🏆 //HANDSHAKE

At this point, Ana asks you if you're ready to "take this to the next stage" and submit the evidence.
Doing so now will only trigger the bad endings, since the evidence gathered so far is not strong enough (see the next section for more details).
Therefore, if you're going for all achievements or for the good endings, reply:
Ana > no
and continue your investigation.
However, if you redecide, you can trigger the bad endings with:
Ana > ready to submit our case

This will enable the final branching for NEUROSCIENTIST vs JOURNALIST endings.
By combining the uppercase letters from her tweets from you get: SOMEPLACESOMETHINGINCREDIBLE@GMAILDOTCOM
Ana > someplacesomethingincredible@gmail.com

You can find the suppliers list in Acolyte_Data/acolyte_core/user/nanomax_server/.ba/abbotB_dataCache (you will need to enable showing hidden files inside the nanomax_server folder)
Ana > research Kirlian Medical Suppl.
Download the audio file from https://www.dropbox.com/sh/oscnd7vxnbuxyh1/AADToleOoag0DOXV8KnhqTZpa?dl=0 and input it into https://academo.org/demos/spectrum-analyzer/
Ana > Annabel Harding Still alive Still awake
Download KIRLIAN_EQUIPMENT_BROADCAST3.zip from https://www.dropbox.com/sh/ru3n7pm1gpukvhj/AADIGElkvkJlnN8LcoFQBryja?dl=0
Ana > at mum's please sos sos sos

👨‍🔬 Sanchez, J (Jack Sachez) (mandatory, from Nanomax Supplier Invoices_Q3)
👨‍🔬 Chau, E (Eileen Chau) (mandatory, from Nanomax Supplier Invoices_Q3)

Ana > PARAGON PROGRAM expenses of any value now only require L Harding approval
Wait for the search to complete.
https://docs.google.com/presentation/d/12MDtzp7QnUTGAlJhBKRWFCeWONmLXqXh/edit#slide=id.p1
Ana > The AMICUS trials were vital in discovering our WBE process

Ana > ready to submit our case

If you told Ana the secret email address belonging to Dr. Abbot, you can now pick between sending the evidence to her or to Gwilym Cadwallader.
Each of them awards one mutually exclusive achievement.

If you choose Dr. Abbot, you unlock:
🏆 //THE NEUROSCIENTIST

If you choose Gwilym Cadwallader, you unlock:
🏆 //THE JOURNALIST

👨‍🔬 Eric Davenport (email)

In both paths, continue the dialogue with Ana until you get access to some media files.
https://www.dropbox.com/sh/h20dzmx7shrt9i1/AAAzHc1lSigyRfN4OzfrRx-Da?dl=0

Continue until you reach the end.

Note: If you're going for 100% achievements, then you should probably follow the playthrough from the above sections, since the achievements require to collect all the evidence anyway.

The bad endings seem to trigger when you are ready to submit your case, but you don't have a solid enough evidence.
Therefore, in order to reach them you'll need to do the following:
- use the walkthrough from the above sections and play all the way through unlocking Dr. Abbot's cache (including that section)
- you can research Dr. Abbot's hidden message - this will enable the final branching (for the NEUROSCIENTIST / JOURNALIST paths); otherwise you'll automatically be forced into the JOURNALIST path.
- do not inquire about Terry or Norman (these will unnecessarily complete entries in your evidence list)
- do not investigate the supplier invoices unless somehow the bad ending does not trigger
- do not ask about the Paragon Program
- when Ana asks you if you're ready to "take this to the next stage" and submit the evidence:
Ana > yes

What follows is a set of emails with the consequences of your decision. This come in very slowly - I am not certain what triggers them but they do seem to appear at rather odd times and after minutes of waiting, or after exchanging a few lines with Ana / changing between various screens in the game.
If you're bored of waiting or nothing happens for a considerable amount of time, you can try unlocking a few more pieces of evidence, for example by investigating the supplier invoices.
Eventually Ana will glitch out and trigger the ending sequence (for me this happened when I had 27 / 34 evidence gathered, including completing the supplier invoices task but not the Paragon Program one).

Sometimes during the gameplay, your acolyte is busy gathering data for one of your lines of investigations.
This is the perfect time to go for these achievements, until the next event triggers:

Ana > Can I rename you?
🏆 //(RE)ACQUAINTANCE

Ana > Tell me a joke
🏆 //STAND UP

Ana > Tell me an interesting fact about you
🏆 //GENERAL INTELLIGENCE

Ana > Let's play a game
Ana > umbrella
Ana > a book
Ana > a dress
Ana > coffee
Ana > pizza
Ana > balloons
🏆 //PARTY GAME

Ana > [submit bug] write anything here
Ana > [submit bug] write anything here
Ana > [submit bug] write anything here
Ana > [submit bug] write anything here
Ana > [submit bug] write anything here
🏆 //TEACHERS PET

Hairstyle 1-4: unlocked by default
Hairstyle 5: Artemis (can be unlocked only after jailbreak)
Hairstyle 6: 12970389 (can be unlocked only after submitting the evidence; total sum of the entries in the suppliers document)
🏆 //CUT ABOVE THE REST

Outfit 1-3: unlocked by default
Outfit 4: Tartarus1! (can be unlocked only after jailbreak; unlocked by scanning the QR code from the promo video at the 40s timestamp)
Outfit 5: JustLikeThis! (can be unlocked only after submitting the evidence; from the user manual, Ana will email it to you if you input 'user manual')
🏆 //DRESS FOR SUCCESS

App background 1-2: unlocked by default
App background 3: city or country, depending on what you picked during the personality test
App background 4: automatically unlocked after jailbreak (city / country)
App background 5: EC1 9BD (can be unlocked only after jailbreak; office postcode, as part of the address listed at the bottom of the Nanomax website)
App background 6: 0112358132 (can be unlocked only after jailbreak; first 10 digits of the Fibonacci sequence)
App background 7: snicker-snack (can be unlocked only after submitting the evidence; easily found via a web search)
App background 8: Atlantis3022 (can be unlocked only after submitting the evidence; found in the install folder of the game under Acolyte_Data\acolyte_core\wardrobe\a_bgs\7)
🏆 //SET THE SCENE

If you followed the guide and clicked all evidence entries in your tracker, you should already have obtained:
🏆 //DOTTING THE Ts AND CROSSING THE Is

👨‍🔬 Ana Acolyte (automatically added)
👨‍🔬 Shanon Bright (her name appears when you inquire about Robert Ford)
👨‍🔬 Michael Carnell (from the Nanomax blog)
👨‍🔬 Chau, E (Eileen Chau) (from Nanomax Supplier Invoices_Q3)
👨‍🔬 Ann-Marie Clarke (from the email sent after deciphering the strange audio)
👨‍🔬 Eric Davenport (email)
👨‍🔬 Robert Ford (automatically added after the first email read)
👨‍🔬 Roy -> Roy Gilby (reference from Nicholas Jackson's email)
👨‍🔬 Lisa Harding (automatically added after the first email read)
👨‍🔬 John Harris (email)
👨‍🔬 Danielle Holdway (automatically added after the first email read)
👨‍🔬 Nanomax HR (automatically added after the first email read)
👨‍🔬 Nicholas Jackson (automatically added after the first email read)
👨‍🔬 Jennifer Khan (automatically added after the first email read)
👨‍🔬 Terry Mansel ("Nanomax HR - Terry Mansell Anniversary" email)
👨‍🔬 Fiona Nightingale (email)
👨‍🔬 Dev Prakash ("Nanomax IT Desk - Acolyte 0.8.2 Update" email)
👨‍🔬 Phillip Richards (email)
👨‍🔬 Sanchez, J (Jack Sachez) (from Nanomax Supplier Invoices_Q3)
👨‍🔬 Daniel Tan
👨‍🔬 Harry Tate (referenced in the "Fiona Nightingale in Cabled" article available under "The Latest from Nanomax" section about your task list)
👨‍🔬 DEEP_THOUGHT (automatically added after the first email read)
👨‍🔬 Grace Tyler (automatically added after the first email read)
👨‍🔬 Laura Young (she sets the password for Hairstyle 5)
🏆 //HEADCOUNT