First of all pick any character in the game, doesn't matter who but obliviously if you are going for dead god you might want to focus on unlocks.

Now THIS is where we get in to the good part, the real meat of this guide truly detailing how to win every run easily,
Put simply don't take damage, its really not that hard guys I mean if you have ever died on floor one, uninstall the game, how the ♥♥♥♥ you gonna die to ♥♥♥♥ moving slower than a sloth.
Want proof this works? No Problem Check This Video.
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https://youtu.be/spPs2s1mrPc