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ICBM increases the amount of missiles your 'shift' button shoots by 2 (assuming you aren't using the shield), and additional stacks of ICBM increase the damage of all your missiles (both from your shift, AtG, and Disposable Missile Launcher) by 50%. You can pair this with Hardlight Afterburner to further lower its cooldown by 33% as well as having 2 extra charges of your shift ability.
This combo makes it where you can shred bosses and instantly delete stages worth of enemies when combined with gas tanks and other AoE items.
Oh and if you want another pro tip: certain defensive items you wouldn't expect also apply to your turrets. Oddly Shaped Opal reduces the initial damage the turrets take (making it effective for keeping em alive late game). Rejuvenation Rack increases the heal tick rate from your turrets Bustling Fungus', and even Dio's revives your turrets once per their life. Not everyone knows this so I just thought I should mention