1. Don't just hold down the R key every time you get a bad item.
2. Play the game with the music. It makes the experience a whole lot better.
3. Buy repentence.
4. Try playing co op! It's a great time.
5. Actually bother to play through the lore and see the deeper story behind the game.
6. Go into every room when you have the chance, see what you find.
7. Don't take the game too seriously :)