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Play the Tutorial
Listen to What the Tutorial Makes You Do
Win
Replay the game with more items unlocked to make it easier
Do Not Try to Complete The Game Experience Only Once

Some Metagame Hints:
Find a Shotgun. Find a Minigun. Anyway find a weapon that does high damage with a slight spread. Cross recitals always hit on the dot while a circle or square hits within the area. Sometimes a weapon that's too accurate is hard to hit, which brings an even more important feature. Every hit is a stun. Try and distribute damage between enemies to prevent attacks. Try and ambush enemies that have ranged attacks with corridor junctions and doors
Use Turrets Offensively as They Do More DPS than your first play though Weapon Loadout. They are most useful when enemies are around the blind corner or door welcome mats
Fully Man The Resource Rooms. Your participating crew members will receive experience for every action that is performed, and that levels them up to become stronger and smarter. They also provide above deck security against resource infiltrators. Link resource rooms together; so if something really bad like invader or pirate class aliens emerge from the tractor beam room, your members on standby in the refinery and hanger can quickly participate without a need of an alien detection upgrade. Don't corridor a holding, just have only one linked to the center access of the refinery room so the aliens won't attack the power connection in the Holding or quickly escape down under deck.
Listen to Audio Logs That You Find. They may contain spoilers of problems ahead.
You can scan every planet system by being 1 tile away from one. Try and warp jump into the center of a planetary system cluster.
Always Scan On the Bridge before You Plan
Trade Unused Resources for Technology at the Traders
Any technology, upgrades, ship rooms you find and build become carry over as starting choices for the new game.
Adding Hyper Drives increase your hazard search radius as well as jump distance. Moving one tile at a time does not use up Fuel Rods.
Aliens can use elevator lifts. Try to keep essential rooms and storage on a different floor from the resource rooms.


FAQ

~The Game Is Too Hard~

You did not do the Tutorial first. The game recommended you to do the tutorial. This is a multiple play though progression game not a speed run completion game. The enemy encounters and the AI are harder outside the tutorial play though. Don't bother adjusting the difficulty either; that's the main problem of why you are losing in the first place.

~The Game Does Not Tell Me Anything~

That is both true and not true. The game only tells you about things that you have built or unlocked. That is why play the Tutorial first because the game forces you to build most rooms that are essential to the mission.

~The Enemies Are Too Hard~
Enemy difficulty is scaled by threat level. Low is tier 1. High is tier 2. Critical is tier 3. The difficulty is balanced by the weapon tiers you have unlocked. The starting tutorial has weak crew members with the default laser pistol while other factions outside the tutorial gave you a high powered shotgun for everyone. However it's not like you would want to face the hardest of the galaxy with an untrained and ill-equipped crew. Learn to avoid strong enemies, they only get harder. This also goes for Genesis Candidate Worlds, with lowest difficulty being I, and highest III. You don’t need to go to high threat areas to beat the game.
Wait until you encounter pirates.

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