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And in BTD6 it insta-bans your account if you use it (1).
There are probably BTD5 mods/hacks online that allow you to do that if you really want to. but yeah.
Source (1): https://support.ninjakiwi.com/hc/en-us/articles/8174850681745-Account-Flagged-for-Hacking
If you are talking about a modified game.exe being bannable then the worst thing that can happen is you being kicked from a co-op game and being told the .exe is invalid.
That is what happens on VAC enabled games (which BTD5 is not) and they do this to prevent people with corrupt files from being banned.
So all-in-all, no, there won't be a ban.