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I just launched game and went into statistics to find what it says and it seems there is no alchemy listed on requirements unless statistics page has a mistake in it.
This guide was written back in June 2021 and i think there was a content patch earlier this year so that may be why, maybe some of the names no longer match up also as there was some bad English when i played it.
Vampires might be immune to that effect.
I do agree with avoiding Bloody curse on a challenge run, but on most general runs you should not have any attacks at all if you managed your reputations properly, so generally it is a curse that has no bad effect. I will add a note about it being worse on harder difficulties and challenges.