For someone who is encountered this "symbol lookup error: /lib64/libk5crypto.so.3: undefined symbol: EVP_KDF_ctrl, version OPENSSL_1_1_1b" error while trying to launch Substance 3D Designer 2021.

Or Substance 3D Designer 2021 refuses to launch, and you have no idea why, better to go to steam folder, and run it through terminal, but it is probably the same problem, so you can try it out, and see if it's fix it or not.

This is quote from the bug report thread, so you have better idea about what may cause this problem: "Both products (Matlab & Scilab) contains their own shared library libcrypto.so.1.1, but uses system library libk5crypto.so.3.
System library libk5crypto.so.3 uses new symbols, which system library libcrypto.so.1.1 has, but Matlab's library libcrypto.so.1.1 hasn't."
Yes it's about different software, but problem are same.

THE FIX
So fix is pretty simple, just delete this file libcrypto.so.1.1 from home/USERNAME/.local/share/Steam/steamapps/common/Substance Designer 2021/
This path is by default, your path may be different.
Or just move it somewhere if you not sure, to check it out if problem is solved.

I've found this solution here: https://bugzilla.redhat.com/show_bug.cgi?id=1829790

Для тех у кого выдаёт ошибку "symbol lookup error: /lib64/libk5crypto.so.3: undefined symbol: EVP_KDF_ctrl, version OPENSSL_1_1_1b" при попытке запустить Substance 3D Designer 2021.

Или Substance 3D Designer 2021 не запускается, можно пойти в папку со стимом и запустить программу через терминал, но это скорее всего по той же причине, так что можете попробовать и посмотреть - работает или нет.

Цитата(ENG) с треда с багом, мало ли кому интересно, это про другой софт, но проблема та же: "Both products (Matlab & Scilab) contains their own shared library libcrypto.so.1.1, but uses system library libk5crypto.so.3.
System library libk5crypto.so.3 uses new symbols, which system library libcrypto.so.1.1 has, but Matlab's library libcrypto.so.1.1 hasn't."

РЕШЕНИЕ
Решение простое - удалить файл libcrypto.so.1.1 из папки home/ПОЛЬЗОВАТЕЛЬ/.local/share/Steam/steamapps/common/Substance Designer 2021/
Ну или оттуда куда установили.
Можно просто переместить куда-нибудь, на всякий случай, чтобы проверить починилось или нет.

Решение нашёл тут - https://bugzilla.redhat.com/show_bug.cgi?id=1829790