Enter the game's directory, and remove the file 'libGLESv2.dll'. The game can now be run using either WINE or using Proton through Steam.

WINE has had problems with the Window's version of OpenGL ES for a long time. By deleting 'libGLESv2.dll', WINE (or Proton) will fall back to the native version and run without problems.

Unlike the previous Team Sigyaad visual novels, 'Save me, Sakuya-san' uses TyranoBuilder rather than Ren'py, and it thus doesn't come with a script to run the game natively on Linux. The above fix can be applied to many other TyranoBuilder games, and other applications.

Tux image by Larry Ewing, made in GIMP.