Beat the game for the first time.

Resident Evil 7: Biohazard has 3 difficulties in the main game: Easy, Normal, and Madhouse. Madhouse is only unlocked after completing the game for the first time or by purchasing certain DLCs.

Main Game
Beat the game for the first time.

Nightmare
Obtain 5,000,000 points in the Nightmare mini-game. it can be crafted for 200 Scrap.

Ethan Must Die
It can be randomly acquired in 4-star ranked chests.

A functioning replica of the anti-bioweapon handgun. Even though it's a replica, it still packs a punch.

Main Game
Beat the game in under 4 hours.

Nightmare
Obtain 10,000 points in the Nightmare mini-game. it can be crafted for 3,000 Scrap.

Jack's 55th Birthday
Circular Saw is unlockable with a B Rank in Guest House 2.

A standard circular saw. Can be used as a weapon.

Main game
Beat the game in under 4 hours.

Ethan Must Die
one pair of X-ray Glasses may spawn as a drop from a 2-star or better crate.

Improves your vision so you can see where items are located.

Beat the game in Normal difficulty.

Reduces damage when guarding. Effects are maximized when paired with "The Essence of Defense.

Destroy all Mr. Everywhere statues.

Reduces damage when guarding. Effects are maximized when paired with "The Secrets of Defense.

Destroy all Mr. Everywhere statues.

Light shoes to make walking more comfortable. Increases walking speed, but running speed stays the same.

Main Game
Beat the game in Madhouse difficulty.

Nightmare
Obtain 10,000,000 points in the Nightmare mini-game.

Not a Hero
Complete Not a Hero on Professional difficulty.

An infinite amount of ammo. It'll never run out no matter how much you use.

Beat the Demo with the Dirty Coin in the inventory.
https://store.steampowered.com/app/530620/Resident_Evil_7_Teaser_Beginning_Hour/

An old, commemorative coin. It has something that looks like mold sticking to it.

The Dirty Coin is only meant to be collected to be later transferred to the player's save file in Resident Evil 7 Biohazard.

If the player obtained the Dirty Coin in the demo, it will appear in the Item Box of the main game. The Dirty Coin functions as an extra Antique Coin, which is used to unlock power-ups or weapons through the course of the game.

Pre-order bonus.
https://store.steampowered.com/app/418370/Resident_Evil_7_Biohazard/

Supply Box is an item. It is only available to those who have pre-ordered the game that contains the Survival Pack: Recovery Set.

The Supply Box will be put in the Item Box upon redeeming the code. The player needs to use the Supply Box from the inventory screen in order to open it. Opening it will reveal a First Aid Med, Strong First Aid Med and two Herbs.

Purchase the 5-COIN SET & MADHOUSE MODE UNLOCK Bundle.

Defense, Attack, Instinct, Reload and Universal Coins
Keep these in your inventory to get various stat boosts. Coins are added to your item box, and can be used in both the main game and the Not a Hero free additional story chapter. Effects stack when holding multiple coins.
=
Madhouse difficulty level unlock
Unlocks the insanely difficult Madhouse mode, which normally only becomes available after completing the game.

Zoe Baker

if Ethan cured Zoe, Mia succumbs to Eveline's control and attacks Ethan, forcing him to kill her.