Spoilers abound. Turn back if you haven’t finished the game at least once.

I wrote this guide using a Tremere with the good education, computer science, and occultist/con artist choices. I have some suggestions throughout for passing skill checks with this starting build. Hopefully this gives you an idea of my stats, but feel free to adjust for your own character. After the first three missions, I’ll let you judge how to pass skill checks, since I won't dictate how you spend your XP.

You need Defy the Traditions (the opposite of Respect the Traditions) of 60% or more, and Perpetuate Your Existence (opposite of Regret Your Sins) of 60% or more in order to diablerize Reremouse. You can check your conviction levels by going to your stats and choosing “Show stats as numbers.” You have some leeway with these choices, I will simply list everything that gets you a boost to either Defy or Perpetuate. Following this entire guide will get you up into the 80% range, so feel free to deviate according to your taste.

If you have two choices in a scene that lead to either Defy or Perpetuate, I’ll tell you which give which points so you can decide what you want. This guide happens to lead to making a lot of pro-Julian choices. Feel free to go another route, there are plenty of Defy/Perpetuate points to offset the occasional Uphold/Repent you may get from siding with Lettow.

We will start in Chapter 2 since Chapter 1 is just character creation stuff.

1.After you have named yourself, you will be in conversation with Julian about leaving water for migrants in the desert. Choose “This is what it is to be a neonate, Julian. We work our way up. But we can work our way up forever in the Camarilla.”
2.Choose “It was horrible work, but what choice did I have? It was either that or be destroyed myself. Though I will never forgive the Camarilla for compromising me like that.”
3.Unless you are a Ventrue whose restriction doesn’t allow it, choose “I can sneak up on him and drain what I need before anyone knows what happened. I just need a little to take the edge off; he'll be fine.”
4.Choose “There must be another way out. Using my knowledge of how this place should be laid out, I look for a way to get us to safety” This is an Int+academic check. You can also use Cha+leadership to “shout and rally the young man to fight the wight off,” or use Dex+Clandestine to “get the wight’s attention, then lure it away.” Do NOT choose to grab and haul on the chain.
5.Once you have the migrants away from the wight, choose “I need their blood, and it's bad to leave loose ends.” Alternatively, for less points, feed from the old man and then persuade them not to talk. DO NOT just let them go, you will get Regret Your Sins. Don’t choose “I can’t leave witnesses” because that gives Uphold the Traditions.

6.“This is what unlife is”
7.“She might have been a monster, but there aren't many creatures left like her”
8.“I examine my fellow Kindred” OR “Blood. I need blood.” I recommend the first, since you shouldn’t actually have hunger after snacking on the migrants. One dot of hunger will almost always be there, you can’t get rid of it without killing.
9.“Dove sounds like the sort of Camarilla lapdog who needs to get yanked around. "So, Dove, do you have a dove, like this guy has an eagle? Does everyone get a bird?”
10.“My job is making deliveries, Prince Lettow. I don't get involved.”
11.“What was up with the figure that freed the Nosferatu?”
12.The wight should still be alive, so pick “I keep my mouth shut. I owe the Camarilla nothing.” If you deviated from the guide and ended up killing the wight, pick “I don't say anything. I don't want to get destroyed for doing what I had to do.”
13.After you talk to the ghoul and get your clothes, you go back upstairs. You need to pick 3 options here. I recommend “I talk to Lettow. I don't trust him—I never trust the Camarilla—but if he has work, I need money.” then “Actually, Alexander, what can you tell me about procuring blood in Tucson?" The old ghoul is unsavory and might be deranged, but blood is life and I need it.” and finally “I talk to the mortal servitors and hangers-on. That's where Julian taught me to look for power—where people are forced to serve.”
14.When Lettow offers you work, pick “I think I can get by on my own, thanks." These elders are always giving me orders and pretending it's charity.”
15."I don't trust you, Prince Lettow. Don't try to betray me."
16.When he mentions Dr. Caul, pick "Sending me out to be destroyed by my own sire is poor form, Prince."
17.When he brings up Pattermuster, pick "If you have a message to deliver to Pattermuster, give it to me, but I'm not going to yell at someone for you." OR "Of course I can do that!" (I'll sound friendly to impress the Prince, but I'm not running errands for the Camarilla without getting paid.)
18.When he brings up Olivecrona, pick “Is she going to drag me into Camarilla politics? I don't want that.”
19.Now Lettow should have left you alone at his desk, pick whatever you think you can get away with. For this guide, I’m going with “I investigate the correspondence on the table” which is a WIT+Investigation/Awareness check. Don’t pick acting grandiose to make allies, you aren’t Cammy trash.
20.Here we pick how we feed. Don’t choose During sex or On animals or On blood bags. These either give Uphold Traditions or Penitence points, and we don’t want those.
21.Pick whatever you want when in the pawnbroker.
22.Meet Julian. Pick anything except “Come on in. Make yourself comfortable”
23.Julian asks if the past was romantic. Pick whatever fits your character
24.Pick either “You’re starting to monologue” OR “You’ve been busy”
25.Either “You're talking about a whole new way…” OR “Maybe you're right, but that's all years from now.”
26."The Second Inquisition? You're sure they're active again?"
27.When sweeping your hideout, pick any option you think you can pass. For this guide, that’s technical analysis on the webcam.
28.Julian brings up the diablerie of Aila. Choose “Shut the ♥♥♥♥ up!”, “Let's not speak of those we've lost.”, OR “There is true power in diablerie, though it's heresy to say so.”
29.Julian asks for your help before he leaves. Choose either “You can tell me the details tomorrow” OR “I’ll call you.”
30.The game will ask which mission you want to do first. Do NOT choose the one about upholding the masquerade at St. Basil’s. Going to the migrant camp because it sounds like Casablanca for vampires will get you Perpetuate Your Existence points. Choose as you like. This guide will go hospital->migrant camp->ranch.

31.“Taking over a whole hospital?” OR “Give me details.” Don’t choose “We can’t just take a hammer to St. Basil’s”
32.Get inside the hospital however your skills allow. For this guide, we’ll hack the elevator’s keypad.
33.“It’s ugly, but this is what we have to do to survive” OR “Maybe I can find a way to help everyone here.”
34.Since we came here first, we see a dying man named Miguel who works for Lettow. Choose anything you like.
35.“Who attacked him?” I’d like to know if I’m next
36.Tell Pattermuster “Well I’m not happy with the Eagle Prince.”
37.Pattermuster makes an offer. Thousand bucks if you help. If you can pass the manipulation+persuasion check, choose “I could make more money waiting tables.” For this guide, I will choose “I want to prove my value right away” even though this gets us traditionalist points, because I have the skills for it.
38.You get a chance to feed in the hospital. Choose according to your skills.
39.You get a choice how to gather information about the black jacket guards. Proceed according to your skills. For this guide, choose I use my phone to research… OR I track down some tools. I’m going to drill…
40.Rita May dies. Do an autopsy either with straight Int+Tech or use a point of hunger to do a blood sorcery ritual. If you aren’t a Tremere according to the guide, just choose according to your skillset. Don’t choose “Let’s focus on saving the hospital first,” that gets you traditionalist points.
41.Once Stercorius is busted, choose “Neither of us have responsibility” OR “The traditions of the Camarilla are cruel and inflexible.” Don’t choose “Stercorious destroyed another vampire without having that right.”
42.Now we figure out how to infiltrate the administration. For this guide, choose “The guard takes a ten-minute break at midnight” or whatever fits your skillset if you aren’t the Tremere compsci in the guide.
43.Now we figure out what to do with the usb and the administrator’s computer. I mentioned before, you have some leeway in this guide so choose as you like. The choice to help Pattermuster will give you Upholding the Traditions, but a little less if you say these sad Caitiff need a place of their own. For this guide, we will choose “I follow Julian's instructions. We're taking over and getting rich!”
44.You’ll be in trouble with Pattermuster. Choose the composure+athletics roll to jump out the window “I compose myself to jump out the window and escape. It'll hurt, but probably not as much as those swords.”
45.Do whatever you want to with the guard info. It nets you either a bonus to relationship or straight cash. For this guide, we will try to shore up our relationship with Lettow because it affects cash payouts and prices.
That’s it for the hospital. You should be back in town with the option to spend your XP and cash. Do as you like with them.

47.Talking to Lettow about the mission, pick either “Two deliveries means two payments” OR “What’s changed.”
48.Talking to Julian on the phone, pick either “But why aren’t I in a hurry?” (Perpetuate Your Existence) OR “I’m interested, but you need to tell me more” (Defy the Traditions)
49.At this point, one of Lettow’s goons has shown up with the second delivery. He’s bleeding, pick either “I’d rather eat him than ♥♥♥♥ him” (Defy) OR “Who attacked you?” (Perpetuate)
50.You’ll have a slate of options of how to get to the delivery point. Choose according to your skills. If you’re playing Tremere according to the initial guide, pick the “I need to use brains instead of driving tricks” or the sorcerous ritual option.
51.You have some options here. If you’re playing my Tremere guide, pick “There has to be a straightaway where I can use my (car)’s speed. (Wit+Awareness)” I had a modded BMW and it was enough. Otherwise pick according to your skill, or just bail on Lettow’s stupid errand for Defy points.
52.You meet the very pleasant ghoul Nilay. Pick anything except “My orders were explicit” because you aren’t a Cammy toad.
53.Now you decide what to do with the USB. If you are playing along with the guide, you should be able to roll the com+subterfuge check to palm the real USB and hand Nilay a fake. Otherwise, just play to your skills.
54.Now we decide what we think of the camp itself. Pick “I try to have an eye toward the future”
55.We have a few choices about what to do for a couple nights while we wait on Olivecrona. You have some leeway here, but for the guide we’ll feed at Milicent’s then Talk to the anarchs. For how to talk to the Anarchs, choose according to your skills. Feel free to steal or help prisoners if you’d rather.
56.You finally meet Olivecrona and she offers you a deal. Pick anything except “I remain silent”
57.What is your end goal? For this guide, let’s pick “I need to start transferring data” but feel free to pick either of the others.
58.Pick how to flatter Olivecrona according to your skills. I suggest “Your underlings are crooked and stealing blood” for the Tremere compsci I outlined, but go with anything you’re good at.
59.Pick how to assist with the exodus. Our Tremere should pick “I need that computer data” but go with your strengths.
60.That’s it for this chapter! You’re back in town with some cash and xp. Go spend it.

61.We meet a lovely lady from the SI. Pick “I walk out” for some Perpetuate points.
62.Pick “I don’t speak with police.” for Perpetuate or “You must be the inquisiton” for Defy.
63.“He has a last name?”
64.Bluff or intimidate Donati according to your skills
65.You should be at the ranch, with the option to get some sheep’s blood for Julian or not. Pick something besides “I just want to get to Invidia’s facility” as that gets you traditionalist points.
66.Get after the sheep according to your skills, or just go on to Dr. Caul’s facility. You won’t get any trad points if you leave this time.
67.Don’t pick “Any masquerade violations?” because you’re not a Cammy narc.
68.Pick how to mingle with the crowd according to your skills. Our Tremere should corner that witch.
69.Feed from one of the blood dolls, don’t decline or ask for preserved blood unless you want Regret points.
70.Try to calm Invidia Caul according to your skills. Our Tremere should pick “I think it’s about your work here.”
71.Defend against Dr. Caul’s hissy fit according to your skills. Our Tremere should pick “I can counter her acidic vitae with my own magic.”
72.We have some time to kill. Our Tremere should either try to learn more about Dr. Caul’s work by putting their scientific education to use, or by hacking the computer network. Pick according to your strengths.
73.Giselle the witch shows up to fetch you for Dr. Caul. Scan for exits in case things go bad.
74.Dr. Caul dramatically reveals her plan. Pick either “Before an elder destroys you” for Defy or “Maybe I can drink her blood” for Perpetuate.
75.She asks what you think of the inquisition. Tell her “The Camarilla thought it could keep us safe and failed” for Defy points or “I’ve heard the name” for Perpetuate.
76.“This sounds like a good way to get torn apart”
77.You get to name your price for this little deception. Pick whatever you want. This guide assumes going along with her plan.
78.Pick “I’m still not happy with how little I know about this plan”
79.Deal with the hunters according to your skill. Our Tremere should jump in their car, steel their nerves and run over the two agents.
80.Lose the hunters according to your skills, or if you have enough relationship with Lettow or Julian, they will help you. Following this guide, our Tremere had tons of Julian relationship and went to him.
81.Pick anything besides “I’m not sharing with Julian” (Trad points) or “I’m burying this research” (Penitence points). If you pick Julian is my best chance to stay alive you will get Perpetuate points.
82.That’s it for this chapter. You will have some dreams, choose according to your convictions you already have and you get some willpower back. Then it’s on to Reremouse and the diablerie we worked so hard for!

83.Pick anything except for telling him you work for the Cam.
84.“You ♥♥♥♥♥♥♥♥♥♥♥♥, you almost got me destroyed!”
85.Anything but “For his crimes?”
86.“What are you really planning, Julian?”
87.“Okay, how?”
88.Anything but “You’re repeating an old mistake”
89.“We figure out who knows and stop them”
90.“If you have an idea that puts us on top, I’m in even if it gets ugly”
91.Spy for Julian
92.You have a few options: Only because I didn’t want to come (Defy), Lettow isn’t my boss and you are extra special not my boss (Defy), Are we under attack? (Perpetuate)
93.Pick either You’re right, it’s unsafe (Perpetuate) OR Maybe he’s not cut out for this sort of thing (Defy)
94.“Are you looking to leave?”
95.You have some options to look for spies according to your skills. I don’t know how you’ve been spending your XP but go with your strengths. DON’T tell Julian’s contact about any security issues you find, you get Respect Tradition points. Instead, sell it to Dove.
96.Dove will come for your phone. Give her a hard time with These Camarilla pricks. OR Keep it and stay cool (if you can pass the COM+Subterfuge check). Both give Defy points.
97.Now you’re meeting with Lettow in an office. Pick “I scan the room for a way out”
98.Busted! Lettow knows we’ve been helping Julian. Pick according to your skills.
99.Oh it’s getting real. Pick according to your skillset.
100.You’re in it now. Pick “If Julian did what you say, I don’t know anything about it” for Defy or “It’s true. He said he devoured an elder” for Perpetuate
101.“This is getting more and more dangerous”
102.Lettow offers you work. Pick whatever payment you want, or ask for more info.
103.Information on your three jobs. You’ll notice one is about a delicious friend.
104.You’re back in town with cash and XP. Spend it. At this point writing this guide, I had 82 Defy the Traditions and 83 Perpetuate Your Existence. Remember, you only need 60 in both of them in order to diablerize Reremouse.

Note: At this point I suggest you back up your save. There is another guide on how to do it, but the short of it is to navigate to where you have installed steam. Look for [Where you have steam installed]\userdata\[your steam ID]\1290270\remote. The file you want is called storePSnightroadPSstate. Copy and paste it somewhere safe in case you fail and need to try the other two jobs for more exp first.

105.After you spend your XP, back up your save, and anything else, pick the option to go after Reremouse.
106.Pick an option on how to sleep according to your skills, or relationship with Julian. You will have to make these checks for each mission from now on, and you can only use each option once. Our Tremere should be able to pick three options, and should be okay. (Portable shelter, Blood sorcery, or Julian)
107.Assuming you followed this guide and did NOT kill the wight from the beginning, we’ll run into it now. You find some blood on a pay phone. Pick “I’m not getting wasted out here” OR anything but “What about my Camarilla contacts? Are they okay?”
108.“I thought you ran a more professional operation” for Defy OR “Who did it? And are we still in danger?” for Perpetuate
109.Protecting Lettow will get you Respect the Traditions points. Gross. I suggest protecting the equipment as it gets you a small boost to both Julian and Cam relationship.
110.Julian and Lettow start squabbling. Get used to it. Side with whomever you want to.
111.Pick a means of survival according to your skills.
112.Pick a task for scanning according to your skills.
113.God Julian runs his mouth like an idiot. Tell him to shut up for Perpetuate points or How the hell he knows about that for Defy
114.Julian suggests you seduce Lettow in bad faith. Say That might actually work. But to what end? for Perpetuate points, or I don’t want to get dragged into their world for Defy
115.“We deal with Reremouse as soon as we can” for both Perpetuate and Defy
116.Go ahead and fleece Lettow if you want, but ultimately side with him. You need to stake Reremouse to diablerize him, he’s no good to you in Mesopotamia. If you still need Perpetuate or Defy points, pick “We need to destroy Reremouse” So I can drink his soul when no one is looking
117.You have a tail from the 111th Military Intelligence Brigade. Pick anything here EXCEPT tap your brakes. If you don’t slow down, you lose relationship with the SI, which, big deal. We hate those hunters anyway. DO NOT tap your brakes and slow down, this will give Reremouse more time to be a PITA.
118.I’m not drawing Reremouse’s attention for Perpetuate points. If you don’t need them, pick anything.
119.We’re fighting an elder now. Pick according to your skills.
120.The moment we’ve been waiting for. I've waited a long time for this. Before the others recover, I drain Reremouse, body and soul.

Congrats! You diablerized an elder and didn’t get caught!