This guide is about the Acts I and II. I will update it when the second boss doesn't wreck my team.

Tokens
You do NOT keep any tokens you have from your last run

CB mode
Switch to Colorblind mode to have the red color changed to yellow (if you're not colorblind). A interesting change if you're bored of red/white/black.

Boss Fights
Really try to fight the boss on days that you have a positive bonus event, if your current era has such.

Memories
In my opinion, unless you're doing a run to collect all Memories, the Remembrance that raises the drop chance for them is a waste. The ones that raise HP make your higher level Shieldbearers into real tanks, and help chasing the annoying ranged enemies that shoot you every turn before you reach them.

Starting from the second era you may want armor shaving Memories on your Daughters.

Classes
-SS She really is a double edged sword. good interrupts, but weak against heavy armor. Also the best choice imho for a newly germinated daughter if you have at least 1 BM and one SB already, due to the fact that a underleveled Daughter is less vulnerable when ranged.

-BM's Imbued Blade is hard to use, generally don't use it unless you are up against a Larva.