Find link of timestamps at Youtube video description.

To kill Frank, the first thing you need to do is kill everyone else without being noticed. The video walkthrough shows you how to do it step-by-step and below follows the timestamps for each action.
00:42 - Kill 1
00:54 - Kills 2, 3 and 4
02:20 - Kill 5
04:11 - Kills 6 and 7
04:59 - Kill 8
05:21 - Kills 9 and 10
05:38 - Final position for Isabelle
05:58 - Final position for Kate and McCoy
06:19 - Final position for Hector
06:48 - Killing Frank and last cutscene of Desperados 3

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