The yellow slime is a creature of the slime family, which is very dangerous (As I said in my last 2 guides about slimes). Take a look at the stats

Normal Mode

First, we gotta discuss the required equipment for the fight.
You should get a Last Prism and a Mana Flower (and a lotta mana potions) as your weaponry because slimes of the yellow color tank a lot. You also should'nt forget to bring your buff potions. I really recommend the red potion because it basically gives you all the buffs you need. Also, let's not forget the armor - I usually use the creeper armor because it is very op in the curent state of the game, it should net you around 5 billion defense points.




Strategy
Drink the potion and use your last prism on the slimè. And you should maybe put on your armor before the fight.

Expert Mode

No.

rekt