The entire premise of this challenge is to kill one of every non-human enemy in the game, the rules are as follows:


Hardcore mode must be enabled

Difficulty is at max

No fast traveling

No big guns (A-M rifle, missiles or rockets, minigun, fat man etc)

No explosives or fire weapons

No Companions

Small energy weapons only

No console

All story DLC

And that should cover the rules (Feel free to suggest more rules or tweaked rules)

BARK SCORPION

BLOATFLY

CAZADOR

FIRE ANT & ANT QUEEN
+NOMAL ANT

GIANT MANTIS

RADSCORPION & QUEEN

RADROACH

FERAL GHOUL, GLOWING ONE, OVERSEER, REAVER

GHOST PERSON TRAPPER,SEEKER, & HARVESTER

LOBOTOMITE & TEST SUBJECT 1

MARKED MEN

SUPERMUTANT & NIGHTKIN

TRAUMA HARNESS

BIGHORNER

BRAHMIN

CENTAUR & MOE

COYOTE & OTHER DOGS

GIANT RAT & MOLE RAT

YAO GUAI & GHOST OF SHE

SPORE CARRIER & PATIENT ZERO + SPORE PLANT

DEATHCLAW

LAKELURK & KING

GECKO & ALL TYPES

TUNNELER

(Note: Every type has to be killed, check the wiki for all the types)

MEDICAL EYEBOT

ROBO-SCORPION

SECURITRON

GUTSY & MRHANDY

SENTRY BOT

PROTECTRON

CYBERDOGS

ROBOBRAIN

(Note: Every type must be killed, check wiki for all types)