Despite the revulsion axlotl tanks caused in many groups and cultures, by the time the Honored Matres had conquered the planets of the Old Imperium, the Bene Gesserit had adopted them for the creation of gholas to further their cause. The last remaining Tleilaxu Master, Scytale, was coerced into revealing the means of creating synthetic melange to the Bene Gesserit Sisterhood.