**Azumanga Daioh** (あずまんが大王, Azumanga Daiō) is a Japanese four-panel comic strip (yonkoma) manga series written and illustrated by Kiyohiko Azuma. The manga was serialized in *Dengeki Daioh* from 1999 to 2002 and was later adapted into an anime television series, which aired from 2002 to 2003.

The story follows a group of high school girls, their eccentric teachers, and their everyday experiences. It combines slice-of-life comedy with occasional surreal moments. The series is known for its character-driven humor, its unique and quirky cast of characters, and its exploration of mundane yet humorous situations.

Plot
The series centers around a group of high school girls: the intelligent but socially awkward Chiyo Mihama, the energetic and mischievous Osaka (Ayumu Kasuga), the tomboyish and sarcastic Tomo Takino, and the calm and collected Yukari Tanizaki. Their interactions with one another, as well as their relationships with their quirky teachers, make up the series' central comedic themes.

Characters
The main characters include:
- **Chiyo Mihama** – A highly intelligent young girl who enters high school at age 10.
- **Tomo Takino** – An energetic and loud girl with an obsession with being the best student.
- **Ayumu "Osaka" Kasuga** – A girl from Osaka, known for her daydreaming and slow-witted nature.
- **Sakaki** – A quiet, shy, and tall girl who loves animals, particularly cats.
- **Yukari Tanizaki** – The girls' somewhat irresponsible, somewhat immature teacher.
- **Nyamo (Minamo Kurosawa)** – Another teacher, a friend of Yukari, who is much more level-headed and responsible.

Manga
The manga was first serialized in *Dengeki Daioh* in 1999 and was completed in 2002. It was later collected into a total of 4 volumes. The series became very popular for its unique sense of humor, appealing characters, and lighthearted exploration of high school life.

Anime
An anime adaptation of *Azumanga Daioh* was produced by J.C. Staff and aired in Japan from April 8, 2002, to March 29, 2003. The anime closely follows the plot of the manga, although some scenes and characters are added or altered for the animated format.

Reception
*Azumanga Daioh* has been praised for its heartwarming and humorous portrayal of school life, and the series has received a positive reception worldwide. The anime won several awards, and the manga is considered one of the most influential and beloved yonkoma series in history.

Legacy
*Azumanga Daioh* has had a lasting influence on anime and manga, with its combination of everyday school life and quirky humor influencing many later works. The anime's popularity led to a series of DVD releases, video games, and merchandise.