No issues with the port so far from a technical standpoint... My specs are:

CPU: Core i7 4790k @ 4.0GHz
GPU: Nvidia GeForce GTX Titan X (12GB VRAM)
RAM: 16GB

Since this is an Unreal Engine game, tweaking things via configs and ini files seems to be possible. The game menu might lead you to believe you can only play at 30 or 60 FPS, for example, but it's possible to set any frame cap you want through such editing.

As for the game itself - I'm not very far into it yet, but it's Dragon Quest and exactly what I expected! I'll update my review with more points about the game at a later date, just wanted to give an enthusiastic technical reccomendation. One of the better day one experiences with a PC Square Enix title I've yet had.

I've not noticed or experienced any frame rate drops that you could catch with your naked eye, but I haven't gotten to the first big city yet either. (I unlocked the frame rate to be the same as my refresh rate but I've been playing via a Steam link so far so I can lay down on my couch, and I haven't had an FPS counter up).

I haven't tried to play with KB+M but this isn't a game I would want to try with KB+M anyway so that's a moot point for me.

::EDIT:: I doubt anybody will see this edit, but for people wondering about the game itself:

It is definitely Dragon Quest. On default settings, it's probably one of the easiest entries in the series (which isn't a bad thing!), but you can choose a combination of different difficulty modifiers when you make a new game that can turn it into the most difficult Dragon Quest released. So that's nifty.

Encounters are no longer purely random; instead you'll see monsters on the map and you can try to start off fights with an advantage by attacking them with your weapon before the battle starts (knocking off a bit of health); this is kinda similar to ambushing enemies in Persona 5, for example, just much easier to do and much more forgiving to pull off.

Battles are entirely turn based and turn order appears to be determined by the agility stat. Most characters have several different trees of skills to choose from, which feature either weapon abilities or more unique things specific to that character. There's a "Pep Up" system which replaces the Tension mechanic from Dragon Quest VIII; entering a state of being Pepped Up buffs a character's stats and allows them to use "Pep" moves, which are kind of like limit breaks. Taking a page out of Chrono Trigger, many Pep abilities can be combined across characters, allowing for some Pep Up moves to burn two or more party member's Pep status for stronger or otherwise special attacks.

A forge replaces the Alchemy Pot from Dragon Quest VIII, which I mostly prefer. While it was cool that you could essentially throw anything and everything into the Alchemy Pot to try things out, it was annoying that you would then have to walk around for a while til the pot finished "cooking," so to speak. The Forge is instant, however, you can only make things for which you have a recipe. Most of the recipes involve materials you collect from "Sparkly Spots" on the maps (which can be viewed from your maps). Crafting itself involves a small minigame of trying to fill various meters to their sweet spots using a myriad of different abilities that you get as you level up and progress through the game (some abilities are half-power strikes, some are strikes across multiple meters, and so on).

The story is better than it might initially appear. It's definitely a slow burner, and I just now got to the major "twist" of sorts that happens at what I can only assume is maybe halfway through the game? I'm 50 hours in and I don't want to spoil anything, but I was hoping this sort of twist would happen and it did. In any case, the story might feel very slow at the start, but characters will grow on you, there are some touching moments, and in more than one place things got more serious than I would've otherwise expected from this game and the way the first dozen or so hours played out. One problem I have with the story, however, is that there is no "skip cutscene" feature, which is always a problem for me in JRPGs when it comes to replaying them or if you get stuck on a particularly difficult boss and you don't want to hear their evil bad guy speech for the upteenth time. (So far, I've not gotten stuck on any bosses, but just saying.)

I do like how, for the most part, you can play the game and more or less do everything and figure everything out without the assistance of a guide. It doesn't quite feel like things are intentionally obscured or way too difficult to figure out, like some JRPGs can be. Most of the in-game menus and information will help you keep track of whatever items you're trying to gather or quests you're trying to complete and so on.

I'm really really digging it and not getting bored of it at all.