Elisabet Sobeck: Being smart will count for nothing if you don’t make the world better.

Galena: Never forget what it is like to see the world as a child: every autumn leaf is a work of art; every rolling cloud, a moving picture; every day, a new story. We too emerge from this magic, like a wave from the ocean, only to return to the sea. Do not mourn the waves, the leaves and the clouds. Because even in darkness the wonder and beauty of the world never leaves. It's always there, just waiting to be seen again.

Alexandra Drennan: Every human society in recorded history has games. We don't just solve problems out of necessity. We do it for fun. Even as adults. Leave a human being alone with a knotted rope and they will unravel it. Leave a human being alone with blocks and they will build something. Games are part of what makes us human. We see the world as a mystery, a puzzle, because we've always been a species of problem-solvers.

Kid: In front of these (arcade) machines stood some of the coolest uncool people I had ever seen. They were the freaks, the geeks, the misfits, the outcasts, the real rebels, part of something the outside world could not understand, or even knew existed. These guys were all playing, trance-like, totally absorbed, as if they experienced something from another dimension.
... Maybe I could be one of them.

Adam Jensen: Are you more than an A.I. now?
Eliza Cassan: It is difficult for me to designate any kind of intelligence as artifical. It seems that one either understands something or does not. One either does something or does not. Is that no so?
Adam Jensen: It's a little more complicated than that.
Eliza Cassan: Because I am not conscious in the same way you believe you are?

Dan Pinchbeck: There's nothing you can put on screen, there's nothing you can do with audio, there's nothing you can do with dialogue that will ever be as powerful as the player's own imagination, so if you oversell the idea and oversell the image, what you're actually doing is you're not only robbing the player of the opportunity to invest in the game, but you're also fundamentally opting for a weaker tool than what the player can bring to the experience themselves.

Bugenhagen: Cloud says they are trying to save the planet. Honestly, I don't think it can be done. For even if they stop every reactor on the planet, it's only going to postpone the inevitable. [...] But, Nanaki. I've been thinking lately. I've been thinking if there was anything WE could do, as a part of the planet, something to help a planet already in misery... No matter what happens, isn't it important to try?

Mary-Ann Ronan: You can't let yourself be defined by the parts that're broken. You gotta find a way to work with what you got.

* 2B: Everything that lives is designed to end. We are perpetually trapped in a never-ending spiral of life and death. Is this a curse? Or some kind of punishment? I often think about the god who blessed us with this cryptic puzzle and wonder if we'll ever have the chance to kill him.
* Pod 042: I cannot deny the feeling of something ressembling consciousness and emotion being born. Perhaps we now understand that not everything has to have an answer.

Paarthurnax: What is better - to be born good, or to overcome your evil nature through great effort?

Karen Reynolds: Making your own choices doesn't mean you can never fool yourself. [...] For years I fooled myself, thinking I'd find satisfaction into what society expected me to be [...] People should know who they are... and not fake it for anybody.

* Live on your own watch, not on someone else's.
* Failing to succeed does not mean failing to progress.
* The world rarely changes when we watch to see it happen.
* We can appreciate the entire journey by looking back at how far we have come.

Black Mage No. 288: I don't know... Fear? I don't want to stop. And maybe I want to run away from it all. But living in the village with everyone fills me with joy. The joy of living with them far outweighs the fear of death. Isn't it the same for you? Traveling with your friends gives your life meaning.

Adam Jensen: For the first time in history, we have a chance to steal fire from the gods. To turn away from it now - to stop pursuing a future in which technology and biology combine, leading to the promise of a Singularity - would mean to deny the very essence of who we are. No doubt the road to get there will be bumpy, hurting some people on the way. But won't achieving the dream be worth it? We can become the gods we've always been striving to be. We might as well get good at it.

Guybrush: At least I learned something from all of this...
Elaine: What’s that?
Guybrush: Never pay more than 20 bucks for a computer game.
Elaine: A what?
Guybrush: I don't know. I'm not sure why I said that.