Yeah you should definitely play The Binding of Isaac. Pretty good game.

Honestly, fuck Skyrim. It's an entry-level rpg loved by people who don't know much about crpgs, but it honestly doesn't hold up. Fallout New Vegas is where it's at. It's a pretty decent game even without mods, but the expansion packs are amazing. Other than that, there's not much entry level crpgs that I can recommend for the pc.
If there's anything that you absolutely must play, it's Saint's Row 2. Imagine how batshit crazy the GTA games are, then multiply it by a hundred. Think running and gunning people is pretty insane? Well try running into traffic and spraying entire neighbourhoods with feces for insurance fraud.