I have not seen documented anywere is animating the npc_personality_core npc's. So lets change that as I figured it out today.

You can only us scripted_sequence to set an idle animation, it is imposible to use these for dynamic animations. I wouls sugest avoid using these as in Portal 2 they are insainly complex to set up and don't provide the functionality you will need.

The best way to animate npc_personality_core entertys is to use an entry such as logic_relay but can be anything and in the paramitors you put the animation name.

# MyOutput: Trigger
# Target: @sphere "If you want "Wheatley" to speak you need to call it this"
# Target Input: SetIdleSequence "The animation will loop untill it is told a diffrent one or to stop"
# Parameter: sphere_idle_angry "Name of animation"

This will animate the npc's. As a note I just figured this out today. If you can add to this info please do.